Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis. (Q50168938)

PubMed publication ID

29408235

26 February 2018

http://europepmc.org/abstract/MED/29408235

title

Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis (English)

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12 May 2020

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12 May 2020

Shizue Ohsawa

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12 May 2020

Tatsushi Igaki

series ordinal

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12 May 2020

language of work or name

English

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publication date

5 February 2018

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PubMed publication ID

29408235

26 February 2018

http://europepmc.org/abstract/MED/29408235

number of pages

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inferred from page(s)

published in

Developmental Cell

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12 May 2020

volume

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issue

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12 May 2020

page(s)

284-296

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Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo

12 May 2020

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An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism

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The role of ephrins and Eph receptors in cancer

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Mechanical feedback as a possible regulator of tissue growth

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Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing

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Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia

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The brain within the tumor: new roles for axon guidance molecules in cancers.

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CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells

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The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

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Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis

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Listeria monocytogenes invades the epithelial junctions at sites of cell extrusion

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Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila.

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Characterization of epithelial cell shedding from human small intestine.

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JNK mediates TGF-beta1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes

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Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

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Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis.

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Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis

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Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2.

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Ionising radiation induces changes associated with epithelial-mesenchymal transdifferentiation and increased cell motility of A549 lung epithelial cells

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Engulfment is required for cell competition

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Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis.

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12 December 2020

Induction of autophagy during extracellular matrix detachment promotes cell survival

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12 December 2020

Is cell competition relevant to cancer?

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12 December 2020

The epithelial-mesenchymal transition generates cells with properties of stem cells

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12 December 2020

Generation of breast cancer stem cells through epithelial-mesenchymal transition

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12 December 2020

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

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12 December 2020

Apoptotic force and tissue dynamics during Drosophila embryogenesis

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12 December 2020

TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta

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12 December 2020

Rho-kinase and myosin II affect dynamic neural crest cell behaviors during epithelial to mesenchymal transition in vivo

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12 December 2020

Pulsed contractions of an actin-myosin network drive apical constriction

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12 December 2020

An innate immune response of blood cells to tumors and tissue damage in Drosophila

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12 December 2020

A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis

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TGF-beta-induced epithelial to mesenchymal transition

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Characterization of the interface between normal and transformed epithelial cells

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Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila

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The basics of epithelial-mesenchymal transition

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Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut

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P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium

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12 December 2020

Epithelial-mesenchymal transitions in development and disease

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Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells

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12 December 2020

Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis

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ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells

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p53-mediated hematopoietic stem and progenitor cell competition.

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12 December 2020

A role for the epithelial microenvironment at tumor boundaries: evidence from Drosophila and human squamous cell carcinomas.

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Sphingosine 1-phosphate and cancer

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12 December 2020

c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3.

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Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

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12 December 2020

Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia.

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12 December 2020

Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

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12 December 2020

Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis

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12 December 2020

Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells

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Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila.

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12 December 2020

Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila

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12 December 2020

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway.

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12 December 2020

The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium

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12 December 2020

Cell competition and its implications for development and cancer

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12 December 2020

Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.

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12 December 2020

Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure.

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12 December 2020

Loss of Scribble causes cell competition in mammalian cells.

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Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.

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ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis

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New frontiers in cell competition

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12 December 2020

Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding.

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12 December 2020

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

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12 December 2020

Intra-tumour heterogeneity: a looking glass for cancer?

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12 December 2020

A roundabout way to cancer

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12 December 2020

Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes.

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12 December 2020

New emerging roles for epithelial cell extrusion

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12 December 2020

Drosophila neuroblasts: a model for stem cell biology

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12 December 2020

Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia.

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12 December 2020

Understanding the mechanisms and treatment options in cancer cachexia

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Roles of p38 MAPK and JNK in TGF-β1-induced human alveolar epithelial to mesenchymal transition

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12 December 2020

Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling

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Myc-driven endogenous cell competition in the early mammalian embryo

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12 December 2020

Epithelial junctions maintain tissue architecture by directing planar spindle orientation.

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12 December 2020

Mechanisms and mechanics of cell competition in epithelia.

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12 December 2020

Differential proliferation rates generate patterns of mechanical tension that orient tissue growth

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12 December 2020

Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P

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12 December 2020

Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours.

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12 December 2020

Cell competition: how to eliminate your neighbours

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12 December 2020

E-cadherin-mediated cell coupling is required for apoptotic cell extrusion

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12 December 2020

Piezo1 is as a novel trefoil factor family 1 binding protein that promotes gastric cancer cell mobility in vitro

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12 December 2020

Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.

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12 December 2020

Extracellular cleavage of E-cadherin promotes epithelial cell extrusion.

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12 December 2020

Tumour cell invasion: an emerging role for basal epithelial cell extrusion

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12 December 2020

Dissecting tumour heterogeneity in flies: genetic basis of interclonal oncogenic cooperation

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12 December 2020

Filamin acts as a key regulator in epithelial defence against transformed cells

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12 December 2020

Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression

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12 December 2020

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip

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12 December 2020

Apico-basal forces exerted by apoptotic cells drive epithelium folding

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12 December 2020

Defective apical extrusion signaling contributes to aggressive tumor hallmarks

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12 December 2020

Convergence and extrusion are required for normal fusion of the mammalian secondary palate

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12 December 2020

Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2.

1 reference

12 December 2020

Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting

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12 December 2020

Cell mixing induced by myc is required for competitive tissue invasion and destruction

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12 December 2020

Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis

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12 December 2020

Cell competition, apoptosis and tumour development

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12 December 2020

Formation of a Neurosensory Organ by Epithelial Cell Slithering

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12 December 2020

Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance

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12 December 2020

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

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12 December 2020

A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC).

1 reference

12 December 2020

Tissue Crowding Induces Caspase-Dependent Competition for Space

1 reference

12 December 2020

Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions

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12 December 2020

Mechanical cell competition kills cells via induction of lethal p53 levels

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12 December 2020

Epithelial cell extrusion: Pathways and pathologies.

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12 December 2020

Survival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer

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12 December 2020

Plexins function in epithelial repair in both Drosophila and zebrafish.

1 reference

12 December 2020

Cell Competition: Mechanisms and Physiological Roles.

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12 December 2020

Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop

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12 December 2020

Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment

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12 December 2020

EphA2 Drives the Segregation of Ras-Transformed Epithelial Cells from Normal Neighbors

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12 December 2020

Remodeling of adhesion and modulation of mechanical tensile forces during apoptosis in Drosophila epithelium.

1 reference

12 December 2020

Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia.

1 reference

12 December 2020

The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition

1 reference

12 December 2020

Mechanical stretch triggers rapid epithelial cell division through Piezo1.

1 reference

12 December 2020

Topological defects in epithelia govern cell death and extrusion

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12 December 2020

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

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12 December 2020

Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts.

1 reference

12 December 2020

Mechanisms of cell competition emerging from Drosophila studies

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12 December 2020

Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis

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12 December 2020

Cell competition in mammals - novel homeostatic machinery for embryonic development and cancer prevention

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12 December 2020

Correction of aberrant growth preserves tissue homeostasis.

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12 December 2020

Human Cancer Cells Signal Their Competitive Fitness Through MYC Activity

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12 December 2020

Temporal Patterning in the Drosophila CNS.

1 reference

12 December 2020

Spatial constraints govern competition of mutant clones in human epidermis.

1 reference

12 December 2020

JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins

1 reference

12 December 2020

10.1016/J.DEVCEL.2018.01.009

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6207186&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6207186&resulttype=core&format=json

12 May 2020

PubMed publication ID

29408235

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6207186&resulttype=core&format=json