Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma (Q59806022)

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scientific article published on 01 December 2018

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English	Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma	scientific article published on 01 December 2018

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instance of

scholarly article

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stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

review article

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title

Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma (English)

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stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

main subject

hepatocellular carcinoma

1 reference

stated in

PubMed

retrieved

18 November 2019

liver neoplasm

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stated in

PubMed

retrieved

18 November 2019

tumor biomarker

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stated in

PubMed

retrieved

7 August 2019

Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy

1 reference

stated in

PubMed

retrieved

8 August 2019

fludeoxyglucose (18F)

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stated in

PubMed

retrieved

18 November 2019

author

Mijin Yun

series ordinal

3

1 reference

stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

author name string

Misu Lee

series ordinal

1

1 reference

stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

Haeyong Ko

series ordinal

2

1 reference

stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

language of work or name

English

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publication date

1 December 2018

6 references

stated in

PubMed Central

retrieved

3 April 2019

stated in

PubMed Central

retrieved

19 June 2019

stated in

PubMed Central

retrieved

7 August 2019

stated in

PubMed Central

retrieved

8 August 2019

stated in

PubMed Central

retrieved

18 November 2019

stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

number of pages

7

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inferred from page(s)

published in

Yonsei Medical Journal

6 references

stated in

PubMed Central

retrieved

3 April 2019

stated in

PubMed Central

retrieved

19 June 2019

stated in

PubMed Central

retrieved

7 August 2019

stated in

PubMed Central

retrieved

8 August 2019

stated in

PubMed Central

retrieved

18 November 2019

stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

volume

59

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stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

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4 May 2020

issue

10

1 reference

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Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

page(s)

1143-1149

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Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

copyright license

Creative Commons Attribution-NonCommercial 4.0 International

5 references

stated in

Europe PubMed Central

retrieved

3 April 2019

stated in

Europe PubMed Central

retrieved

19 June 2019

stated in

Europe PubMed Central

retrieved

7 August 2019

stated in

Europe PubMed Central

retrieved

8 August 2019

stated in

Europe PubMed Central

retrieved

18 November 2019

on focus list of Wikimedia project

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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12 December 2020

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Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

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c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

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12 December 2020

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Loss of PTEN facilitates HIF-1-mediated gene expression

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

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Clinical usefulness of positron emission tomography with fluorine-18-fluorodeoxyglucose in the diagnosis of liver tumors

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

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Positron emission tomography scanning in the evaluation of hepatocellular carcinoma

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

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Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

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Positron emission tomography with 2-[18F]-fluoro-2-deoxy-D-glucose in oncology. Part IIIb: Therapy response monitoring in colorectal and lung tumours, head and neck cancer, hepatocellular carcinoma and sarcoma

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12 December 2020

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A tabulated summary of the FDG PET literature.

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

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Impact of PTEN expression on the outcome of hepatitis C virus-positive cirrhotic hepatocellular carcinoma patients: possible relationship with COX II and inducible nitric oxide synthase

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

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Glucose transporters: expression, regulation and cancer.

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

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Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

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11C-acetate PET imaging in hepatocellular carcinoma and other liver masses.

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

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Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

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Impact of positron emission tomography on strategy in liver resection for primary and secondary liver tumors

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocellular carcinoma in cirrhosis: incidence and risk factors

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic decoding of hepatocellular carcinoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma

1 reference

stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct regulation of TWIST by HIF-1alpha promotes metastasis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sorafenib in advanced hepatocellular carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA and cancer--focus on apoptosis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor suppressors and cell metabolism: a recipe for cancer growth

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MYC-induced cancer cell energy metabolism and therapeutic opportunities

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hypoxia-inducible transcription factor 1alpha for progression and chemosensitivity of murine hepatocellular carcinoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

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Controlling SIRT1 expression by microRNAs in health and metabolic disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN in liver diseases and cancer

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

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stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase

1 reference

stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

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Management of hepatocellular carcinoma: An update

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stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies for hepatocellular carcinoma therapy and diagnostics: lessons learned from high throughput and profiling approaches.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30450847

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12 December 2020

based on heuristic

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Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of driver genes in hepatocellular carcinoma by exome sequencing

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SL1122-37, a novel derivative of sorafenib, has greater effects than sorafenib on the inhibition of human hepatocellular carcinoma (HCC) growth and prevention of angiogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening for Viral Hepatitis and Hepatocellular Cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TERT promoter mutations in primary liver tumors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-DG-Regulated RIP and c-FLIP Effect on Liver Cancer Cell Apoptosis Induced by TRAIL.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolic fate of acetate in cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative 18F-FDG PET/CT in Patients With Very Early and Early Hepatocellular Carcinoma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Acetate Utilization by Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC).

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

18F-Fluorodeoxyglucose uptake on positron emission tomography/computed tomography is associated with metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30450847

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.3349/YMJ.2018.59.10.1143

1 reference

stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

PMC publication ID

6240564

1 reference

stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

PubMed publication ID

30450847

1 reference

stated in

Europe PubMed Central

PMC publication ID

6240564

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30450847%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 May 2020

 

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