Neuroprotective efficacy of P7C3 compounds in primate hippocampus (Q58695785)

0 references

Cynthia M Schumann

0 references

Erin L Carlson

0 references

Sandra L Taylor

0 references

Edwin Vázquez-Rosa

0 references

Coral J Cintrón-Pérez

0 references

Min-Kyoo Shin

0 references

Noelle S Williams

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Andrew A Pieper

Creative Commons Attribution 4.0 International

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language of work or name

English

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publication date

26 September 2018

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published in

Translational Psychiatry

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volume

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issue

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page(s)

202

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start time

26 September 2018

1 reference

April 2022 Public Data File from Crossref

copyrighted

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(-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia

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P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush

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Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats

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DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice

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Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume

30 November 2018

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P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo

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Ongoing neurogenesis in the adult dentate gyrus mediates behavioral responses to ambiguous threat cues.

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The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after ischemic stroke

30 November 2018

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Protective effect of P7C3 on retinal ganglion cells from optic nerve injury

30 November 2018

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Cacna1c: Protecting young hippocampal neurons in the adult brain

30 November 2018

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Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior.

30 November 2018

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Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis.

30 November 2018

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Hippocampal volume in subjects at clinical high-risk for psychosis: A systematic review and meta-analysis

30 November 2018

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A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients

30 November 2018

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Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke.

30 November 2018

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Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease.

30 November 2018

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30 November 2018

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The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons

30 November 2018

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30 November 2018

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Distinguishing adaptive plasticity from vulnerability in the aging hippocampus

30 November 2018

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Adult Neurogenesis in Humans

30 November 2018

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Cell proliferation is reduced in the hippocampus in schizophrenia

30 November 2018

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Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors

30 November 2018

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Hippocampal neurogenesis, neurotrophic factors and depression: possible therapeutic targets?

30 November 2018

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Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243.

30 November 2018

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Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury.

30 November 2018

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Adult neurogenesis: beyond learning and memory

30 November 2018

1 reference

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P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury

30 November 2018

1 reference

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P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage

30 November 2018

1 reference

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Adult neurogenesis and mental illness

30 November 2018

1 reference

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The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.

30 November 2018

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Why primate models matter

30 November 2018

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Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties

30 November 2018

1 reference

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P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases

30 November 2018

1 reference

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Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury

30 November 2018

1 reference

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Dynamics of hippocampal neurogenesis in adult humans

30 November 2018

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Neurogenesis in the dentate gyrus: carrying the message or dictating the tone

30 November 2018

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Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression

30 November 2018

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Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

30 November 2018

1 reference

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Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

30 November 2018

1 reference

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Characterizing cognitive aging of recognition memory and related processes in animal models and in humans

30 November 2018

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Characterizing cognitive aging of associative memory in animal models

30 November 2018

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Of mice and monkeys: using non-human primate models to bridge mouse- and human-based investigations of autism spectrum disorders

30 November 2018

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Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients

30 November 2018

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Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression

30 November 2018

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Anatomical and functional correlates of human hippocampal volume asymmetry

30 November 2018

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Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

30 November 2018

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Breaking Free of Sample Size Dogma to Perform Innovative Translational Research

30 November 2018

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Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months

30 November 2018

1 reference

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Necessity of Hippocampal Neurogenesis for the Therapeutic Action of Antidepressants in Adult Nonhuman Primates

30 November 2018

1 reference

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Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

30 November 2018

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Postnatal development of the hippocampal formation: A stereological study in macaque monkeys

30 November 2018

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Development of Proneurogenic, Neuroprotective Small Molecules

30 November 2018

1 reference

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Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury

30 November 2018

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Animal models of neuropsychiatric disorders

30 November 2018

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Discovery of a proneurogenic, neuroprotective chemical

30 November 2018

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Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients

30 November 2018

1 reference

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Quantitative analysis of postnatal neurogenesis and neuron number in the macaque monkey dentate gyrus

30 November 2018

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Hippocampal volume in first episode and recurrent depression

30 November 2018

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Antidepressants increase neural progenitor cells in the human hippocampus

30 November 2018

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Postmortem changes in the neuroanatomical characteristics of the primate brain: hippocampal formation

30 November 2018

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30 November 2018

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The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)

30 November 2018

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Adult hippocampal neurogenesis in depression

30 November 2018

1 reference

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Evolutionary and Biomedical Insights from the Rhesus Macaque Genome

30 November 2018

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Functional convergence of neurons generated in the developing and adult hippocampus

30 November 2018

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Neural stem cell proliferation is decreased in schizophrenia, but not in depression.

30 November 2018

1 reference

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Neuronal differentiation in the adult hippocampus recapitulates embryonic development.

30 November 2018

1 reference

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The distribution of serotonergic fibers in the macaque monkey amygdala: an immunohistochemical study using antisera to 5-hydroxytryptamine

30 November 2018

1 reference

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A hypothesis about the role of adult neurogenesis in hippocampal function

30 November 2018

1 reference

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Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults

30 November 2018

1 reference

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Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys

30 November 2018

1 reference

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Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

30 November 2018

1 reference

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Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus.

30 November 2018

1 reference

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Hippocampal-neocortical interaction: a hierarchy of associativity

30 November 2018

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Continuation of neurogenesis in the hippocampus of the adult macaque monkey

30 November 2018

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Hippocampal neurogenesis in adult Old World primates

30 November 2018

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Neurogenesis in the adult human hippocampus

30 November 2018

1 reference

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Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress

30 November 2018

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Post-Natal Origin of Microneurones in the Rat Brain

30 November 2018

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Unbiased stereological estimation of the number of neurons in the human hippocampus

30 November 2018

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Two decades of new drug development for central nervous system disorders

30 November 2018

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Restorative effects of human neural stem cell grafts on the primate spinal cord

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