The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth (Q58113104)

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scientific article published on 26 October 2018

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English	The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth	scientific article published on 26 October 2018

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scholarly article

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30 April 2020

The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth (English)

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30 April 2020

1

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30 April 2020

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Claire G Lineberger

2

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30 April 2020

Nikki A Ford

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30 April 2020

Emily L Rossi

4

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30 April 2020

Arunima Punjala

5

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30 April 2020

Kristina K Camp

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30 April 2020

Bruce K Kimler

7

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30 April 2020

Carol J Fabian

8

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30 April 2020

Stephen D Hursting

9

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30 April 2020

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26 October 2018

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30 April 2020

Breast Cancer Research and Treatment

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30 April 2020

173

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30 April 2020

3

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30 April 2020

545-557

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30 April 2020

Production and metabolism of lignans by the human faecal flora

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumorigenic effect of a mammalian lignan precursor from flaxseed

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lignan and isoflavonoid concentrations in tea and coffee

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phytoestrogen content in foods

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant rel/nfkb genes and activity in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose effects of flaxseed and its lignan on N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterolactone inhibits the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenograftsis attributed to both its lignan and oil components

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterodiol and enterolactone, two major diet-derived polyphenol metabolites have different impact on ERalpha transcriptional activation in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multi-targeted therapy of cancer by genistein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flaxseed and pure secoisolariciresinol diglucoside, but not flaxseed hull, reduce human breast tumor growth (MCF-7) in athymic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen-induced angiogenic factors derived from stromal and cancer cells are differently regulated by enterolactone and genistein in human breast cancer in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Meta-analyses of lignans and enterolignans in relation to breast cancer risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction in Ki-67 in benign breast tissue of high-risk women with the lignan secoisolariciresinol diglycoside

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediagnostic plasma enterolactone levels and mortality among women with breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and herceptin 2 receptor status

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The growing challenge of obesity and cancer: an inflammatory issue

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum enterolactone and prognosis of postmenopausal breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-kappaB signaling in HER2-overexpressing breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum enterolactone levels and mortality outcome in women with early breast cancer: a retrospective cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary energy balance modulates epithelial-to-mesenchymal transition and tumor progression in murine claudin-low and basal-like mammary tumor models

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity enhances nongenomic estrogen receptor crosstalk with the PI3K/Akt and MAPK pathways to promote in vitro measures of breast cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterolactone concentrations and prognosis after postmenopausal breast cancer: Assessment of effect modification and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Flaxseed Lignan Secoisolariciresinol Diglucosideon Preneoplastic Biomarkers of Cancer Progression in a Model of Simultaneous Breast and Ovarian Cancer Development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Regulation of NF-κB Subunits by Phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Citrus flavonoid naringenin reduces mammary tumor cell viability, adipose mass, and adipose inflammation in obese ovariectomized mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterolactone Suppresses Proliferation, Migration and Metastasis of MDA-MB-231 Breast Cancer Cells Through Inhibition of uPA Induced Plasmin Activation and MMPs-Mediated ECM Remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin Signaling Mediates Obesity-associated CSC Enrichment and EMT in Preclinical TNBC Models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating enterolactone concentrations and prognosis of postmenopausal breast cancer: assessment of mediation by inflammatory markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30367332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10549-018-5021-6

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Europe PubMed Central

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30 April 2020

PMC publication ID

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30 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30367332%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

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