Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages (Q57796505)

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scientific article published on 01 October 2018

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English	Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages	scientific article published on 01 October 2018

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27 March 2020

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages (English)

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27 March 2020

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atherosclerosis

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John M. Stafford

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27 March 2020

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Paul A Mueller

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Lin Zhu

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Hagai Tavori

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Katherine Huynh

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Ilaria Giunzioni

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27 March 2020

MacRae F Linton

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Sergio Fazio

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1 October 2018

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27 March 2020

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27 March 2020

138

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27 March 2020

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27 March 2020

1850-1863

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27 March 2020

Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

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https://pubmed.ncbi.nlm.nih.gov/29794082

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Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Complete atherosclerosis regression after human ApoE gene transfer in ApoE-deficient/nude mice

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Lipid and macrophage accumulations in arteries of children and the development of atherosclerosis

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Dramatic remodeling of advanced atherosclerotic plaques of the apolipoprotein E-deficient mouse in a novel transplantation model.

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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LRP: role in vascular wall integrity and protection from atherosclerosis

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Subphysiologic apolipoprotein E (ApoE) plasma levels inhibit neointimal formation after arterial injury in ApoE-deficient mice.

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques

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https://pubmed.ncbi.nlm.nih.gov/29794082

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HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Macrophages in the Pathogenesis of Atherosclerosis

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Regression of atherosclerosis is characterized by broad changes in the plaque macrophage transcriptome

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Phenotypic polarization of macrophages in atherosclerosis

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and Regression

1 reference

https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

based on heuristic

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How an artery heals

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Regression of Atherosclerosis: The Journey From the Liver to the Plaque and Back

1 reference

https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Macrophage Phenotype and Function in Different Stages of Atherosclerosis

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition.

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

1 reference

https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

based on heuristic

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LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.

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https://pubmed.ncbi.nlm.nih.gov/29794082

12 December 2020

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Identifiers

10.1161/CIRCULATIONAHA.117.031702

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27 March 2020

PMC publication ID

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27 March 2020

PubMed publication ID

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