The Mechanism of Protraction of Insulin Detemir, a Long-Acting, Acylated Analog of Human Insulin (Q57599459)

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1 January 2020

title

The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin (English)

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1 January 2020

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1 January 2020

Svend Havelund

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1 January 2020

Anne Plum

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1 January 2020

Ulla Ribel

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1 January 2020

Aage Vølund

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15359587%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Jan Markussen

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1 January 2020

Peter Kurtzhals

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1 January 2020

publication date

1 August 2004

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1 January 2020

published in

Pharmaceutical Research

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volume

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issue

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page(s)

1498-1504

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Subcutaneous absorption of insulin in insulin-dependent diabetic patients. Influence of species, physico-chemical properties of insulin and physiological factors.

1 January 2020

cites work

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12 December 2020

Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo

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Soluble, prolonged-acting insulin derivatives. I. Degree of protraction and crystallizability of insulins substituted in the termini of the B-chain

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The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix

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12 December 2020

Insulin analogs with improved pharmacokinetic profiles

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Insulin glargine: the first clinically useful extended-acting insulin in half a century?

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12 December 2020

Insulin analogues and their potential in the management of diabetes mellitus

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12 December 2020

Comparison of the soluble basal insulin analog insulin detemir with NPH insulin: a randomized open crossover trial in type 1 diabetic subjects on basal-bolus therapy.

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12 December 2020

Pharmacokinetic and pharmacodynamic properties of long-acting insulin analogue NN304 in comparison to NPH insulin in humans

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12 December 2020

Mechanism of protracted metabolic effects of fatty acid acylated insulin, NN304, in dogs: retention of NN304 by albumin

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12 December 2020

Effect of fatty acids and selected drugs on the albumin binding of a long-acting, acylated insulin analogue

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12 December 2020

Physiological insulin replacement in type 1 diabetes mellitus

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12 December 2020

Pharmacokinetics of 125I-labeled insulin glargine (HOE 901) in healthy men: comparison with NPH insulin and the influence of different subcutaneous injection sites.

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12 December 2020

Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell

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12 December 2020

Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs

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12 December 2020

Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.

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12 December 2020

Mode of transcapillary transport of insulin and insulin analog NN304 in dog hindlimb: evidence for passive diffusion

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Monomeric insulins and their experimental and clinical implications

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12 December 2020

Diffusion and polymerization determines the insulin absorption from subcutaneous tissue in diabetic patients

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12 December 2020

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12 December 2020

Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo

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12 December 2020

Subcutaneous Insulin Absorption Explained by Insulin's Physicochemical Properties: Evidence From Absorption Studies of Soluble Human Insulin and Insulin Analogues in Humans

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12 December 2020

Receptor Binding and Tyrosine Kinase Activation by Insulin Analogues With Extreme Affinities Studied in Human Hepatoma HepG2 Cells

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12 December 2020

Time-action profile of the soluble, fatty acid acylated, long-acting insulin analogue NN304

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12 December 2020

Action Profile of Cobalt(III)-Insulin: A Novel Principle of Protraction of Potential Use for Basal Insulin Delivery

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12 December 2020

Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart

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12 December 2020

Insulins today and beyond

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12 December 2020

Crystal structure of a prolonged-acting insulin with albumin-binding properties

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12 December 2020

Monomeric insulins obtained by protein engineering and their medical implications

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12 December 2020

Insulin formulations--a review

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12 December 2020

Variation in125i-insulin absorption and blood glucose concentration

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12 December 2020

Structural effects of protein lipidation as revealed by LysB29-myristoyl, des(B30) insulin

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12 December 2020

Measurement of interstitial albumin in human skeletal muscle and adipose tissue by open-flow microperfusion

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12 December 2020

Soluble, prolonged-acting insulin derivatives. II. Degree of protraction and crystallizability of insulins substituted in positions A17, B8, B13, B27 and B30

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12 December 2020

Albumin binding of acylated insulin (NN304) does not deter action to stimulate glucose uptake

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12 December 2020

10.1023/B:PHAM.0000036926.54824.37

Identifiers

DOI

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1 January 2020

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