Big-data and machine learning to revamp computational toxicology and its use in risk assessment (Q57497724)

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scholarly article by Thomas Luechtefeld et al published 1 September 2018 in Toxicology research

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English	Big-data and machine learning to revamp computational toxicology and its use in risk assessment	scholarly article by Thomas Luechtefeld et al published 1 September 2018 in Toxicology research

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scholarly article

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title

Big-data and machine learning to revamp computational toxicology and its use in risk assessment (English)

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main subject

toxicology

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machine learning

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based on heuristic

inferred from title

big data

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author

Thomas Hartung

object named as

Thomas Hartung

series ordinal

3

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author name string

Thomas Luechtefeld

series ordinal

1

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Craig Rowlands

series ordinal

2

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language of work or name

English

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publication date

1 September 2018

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published in

Toxicology research

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volume

7

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issue

5

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page(s)

732-744

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cites work

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2 November 2018

Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information.

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2 November 2018

Making big sense from big data in toxicology by read-across

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2 November 2018

Toward Good Read-Across Practice (GRAP) guidance

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2 November 2018

Supporting read-across using biological data

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2 November 2018

Analysis of publically available skin sensitization data from REACH registrations 2008-2014

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2 November 2018

Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data

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2 November 2018

Analysis of public oral toxicity data from REACH registrations 2008-2014.

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2 November 2018

Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014

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2 November 2018

Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy.

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2 November 2018

Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data

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2 November 2018

Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships.

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Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making

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2 November 2018

Regulating chemicals: law, science, and the unbearable burdens of regulation

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From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods.

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Integrated Testing Strategies (ITS) for safety assessment.

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Read-across approaches--misconceptions, promises and challenges ahead

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2 November 2018

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA).

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2 November 2018

Big data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicants

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2 November 2018

Green toxicology

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2 November 2018

Profiling animal toxicants by automatically mining public bioassay data: a big data approach for computational toxicology

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2 November 2018

The added value of the 90-day repeated dose oral toxicity test for industrial chemicals with a low (sub)acute toxicity profile in a high quality dataset

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2 November 2018

Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods

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2 November 2018

Look back in anger - what clinical studies tell us about preclinical work

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2 November 2018

Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice.

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2 November 2018

Mechanistic validation.

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Integrated testing strategies for safety assessments

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2 November 2018

Evidence-based toxicology – the toolbox of validation for the 21st century?

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2 November 2018

Food for thought...on alternative methods for chemical safety testing

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2 November 2018

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the transatlantic think tank for toxicology (t(4)).

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2 November 2018

Food for thought ... on in silico methods in toxicology

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Chemical regulators have overreached

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ECVAM's ongoing activities in the area of acute oral toxicity

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Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59

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2 November 2018

A modular approach to the ECVAM principles on test validity.

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2 November 2018

Use of QSARs in international decision-making frameworks to predict health effects of chemical substances

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Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs

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The Concave-Convex Procedure

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Diagnosis: toxic!--trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations

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Food for thought ... on validation

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Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats

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TOXICOLOGY. A crystal ball for chemical safety

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ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

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Identifiers

DOI

10.1039/C8TX00051D

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PMC publication ID

6116175

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PubMed publication ID

30310652

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