Re-thinking Alzheimer's disease therapeutic targets using gene-based tests (Q57479938)

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English	Re-thinking Alzheimer's disease therapeutic targets using gene-based tests	article

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scholarly article

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title

Re-thinking Alzheimer's disease therapeutic targets using gene-based tests (English)

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main subject

Alzheimer's disease

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author

C. Mary Schooling

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3

object named as

C. Mary Schooling

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author name string

Man Ki Kwok

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1

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Shi Lin Lin

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2

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C Mary Schooling

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3

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C. Mary Schooling

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3

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language of work or name

English

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publication date

9 October 2018

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October 2018

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published in

EBioMedicine

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cites work

Selective loss of central cholinergic neurons in Alzheimer's disease

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The cholinergic hypothesis of geriatric memory dysfunction

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Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

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A hundred years of Alzheimer's disease research

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DrugBank: a knowledgebase for drugs, drug actions and drug targets

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Network pharmacology: the next paradigm in drug discovery

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Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices?

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The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

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How citation distortions create unfounded authority: analysis of a citation network

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Drugs for Alzheimer's disease: are they effective?

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Network medicine: a network-based approach to human disease

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The Effect of Survival Bias on Case-Control Genetic Association Studies of Highly Lethal Diseases

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GATES: A Rapid and Powerful Gene-Based Association Test Using Extended Simes Procedure

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Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

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Network-based methods for human disease gene prediction

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N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease

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The discovery of Alzheimer's disease

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Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System

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Use of genome-wide association studies for drug repositioning

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Alzheimer's therapeutics: continued clinical failures question the validity of the amyloid hypothesis-but what lies beyond?

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Network-based drug repositioning

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Network.assisted analysis to prioritize GWAS results: principles, methods and perspectives

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

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Data, information, knowledge and principle: back to metabolism in KEGG

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Rational drug repositioning by medical genetics.

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Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease

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Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

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Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

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MS4A Cluster in Alzheimer's Disease

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Statins for the treatment of dementia

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Alzheimer's disease drug-development pipeline: few candidates, frequent failures

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Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

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GWAS and drug targets

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Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus

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Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis

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Rarity of the Alzheimer disease-protective APP A673T variant in the United States

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A pivotal moment in Alzheimer's disease and dementia: how global unity of purpose and action can beat the disease by 2025.

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Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia.

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Clearance of amyloid β-protein and its role in the spreading of Alzheimer's disease pathology

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Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

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12 December 2020

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The support of human genetic evidence for approved drug indications

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A computational framework for the prioritization of disease-gene candidates

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Deciphering the Causal Role of sPLA2s and Lp-PLA2 in Coronary Heart Disease

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Network-based in silico drug efficacy screening

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Alzheimer's disease

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Common variant in PTK2B is associated with late-onset Alzheimer's disease: A replication study and meta-analyses

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DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing

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Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence

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Pharma pumps up anti-tau Alzheimer pipeline despite first Phase III failure

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Interpretation of the evidence for the efficacy and safety of statin therapy

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Drug development in Alzheimer's disease: the path to 2025

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Genenames.org: the HGNC and VGNC resources in 2017

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Genetically decreased vitamin D and risk of Alzheimer disease.

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Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

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Genomic variants, genes, and pathways of Alzheimer's disease: An overview

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Transethnic genome-wide scan identifies novel Alzheimer's disease loci

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The Drug Repurposing Hub: a next-generation drug library and information resource

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Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study

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Analyzing the genes related to Alzheimer's disease via a network and pathway-based approach

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Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk

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Alzheimer Disease: Scientific Breakthroughs and Translational Challenges

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Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals.

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Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry

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Alzheimer's drug-development pipeline: 2016.

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DDR: Efficient computational method to predict drug-target interactions using graph mining and machine learning approaches.

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Trial of Solanezumab for Mild Dementia Due to Alzheimer's Disease

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Disconnect Between Genes Associated With Ischemic Heart Disease and Targets of Ischemic Heart Disease Treatments.

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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

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Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.

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A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

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12 December 2020

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Alzheimer's disease master regulators analysis: search for potential molecular targets and drug repositioning candidates.

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Gene expression-based drug repurposing to target aging

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Identifiers

DOI

10.1016/J.EBIOM.2018.10.001

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PMC publication ID

6446018

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PubMed publication ID

30314892

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