Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability (Q57292153)

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27 April 2020

title

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability (English)

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mitochondrial degradosome

27 April 2020

main subject

genome instability

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27 April 2020

Sonia Silva

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27 April 2020

Lola P Camino

series ordinal

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27 April 2020

language of work or name

English

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publication date

9 October 2018

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Proceedings of the National Academy of Sciences of the United States of America

27 April 2020

published in

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volume

115

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issue

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page(s)

11024-11029

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The yeast nuclear gene suv3 affecting mitochondrial post-transcriptional processes encodes a putative ATP-dependent RNA helicase

27 April 2020

cites work

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12 December 2020

Monoclonal antibodies to double-stranded RNA as probes of RNA structure in crude nucleic acid extracts

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12 December 2020

Monoclonal antibody assay for detection of double-stranded RNA and application for detection of group A and non-group A rotaviruses

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12 December 2020

Priming of human mitochondrial DNA replication occurs at the light-strand promoter

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12 December 2020

Mitochondrial RNA turnover in the presence of cordycepin

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12 December 2020

Properties of cloned and expressed human RNase H1.

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12 December 2020

Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA

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12 December 2020

Protein components of mitochondrial DNA nucleoids in higher eukaryotes

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12 December 2020

Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

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12 December 2020

Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change

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12 December 2020

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability

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12 December 2020

The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.

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12 December 2020

Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality

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12 December 2020

Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD

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12 December 2020

Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells

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12 December 2020

Ribonuclease H: the enzymes in eukaryotes

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12 December 2020

Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality

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12 December 2020

Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance

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12 December 2020

Mitochondrial DNA (mtDNA) biogenesis: visualization and duel incorporation of BrdU and EdU into newly synthesized mtDNA in vitro.

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12 December 2020

PNPASE regulates RNA import into mitochondria

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12 December 2020

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates

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12 December 2020

The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus

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12 December 2020

RNA processing in human mitochondria

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12 December 2020

Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation

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12 December 2020

Genome instability and transcription elongation impairment in human cells depleted of THO/TREX

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12 December 2020

RNA degradation in yeast and human mitochondria

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12 December 2020

R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters

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12 December 2020

R loops: from transcription byproducts to threats to genome stability

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12 December 2020

Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan

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12 December 2020

The post-transcriptional life of mammalian mitochondrial RNA.

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12 December 2020

LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria

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12 December 2020

Fiji: an open-source platform for biological-image analysis

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12 December 2020

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

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12 December 2020

Human mitochondrial RNA decay mediated by PNPase-hSuv3 complex takes place in distinct foci

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12 December 2020

The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression

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12 December 2020

R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity

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12 December 2020

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

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12 December 2020

Ribonuclease III mechanisms of double-stranded RNA cleavage

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12 December 2020

R loops are linked to histone H3 S10 phosphorylation and chromatin condensation

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12 December 2020

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts

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12 December 2020

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

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12 December 2020

Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis

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12 December 2020

Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids

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12 December 2020

RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.

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12 December 2020

SUV3 helicase is required for correct processing of mitochondrial transcripts

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12 December 2020

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication

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12 December 2020

R loops: new modulators of genome dynamics and function

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12 December 2020

RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.

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12 December 2020

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

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12 December 2020

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

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12 December 2020

S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation.

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12 December 2020

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria

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12 December 2020

Transcription-replication conflicts: how they occur and how they are resolved

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12 December 2020

Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability

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12 December 2020

RNase H enables efficient repair of R-loop induced DNA damage

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12 December 2020

Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.

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12 December 2020

Human SUV3 helicase regulates growth rate of the HeLa cells and can localize in the nucleoli.

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12 December 2020

A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture

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12 December 2020

DNA-RNA hybrids: the risks of DNA breakage during transcription

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12 December 2020

Histone Mutants Separate R Loop Formation from Genome Instability Induction

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12 December 2020

Live imaging reveals the dynamics and regulation of mitochondrial nucleoids during the cell cycle in Fucci2-HeLa cells

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12 December 2020

Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq.

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12 December 2020

R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters.

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12 December 2020

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

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12 December 2020

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1807258115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30301808%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

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27 April 2020

PubMed publication ID

30301808

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30301808%20AND%20SRC:MED&resulttype=core&format=json