New Insights into Development of Transglutaminase 2 Inhibitors as Pharmaceutical Lead Compounds (Q57295209)

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English	New Insights into Development of Transglutaminase 2 Inhibitors as Pharmaceutical Lead Compounds	article

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instance of

scholarly article

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stated in

Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

title

New Insights into Development of Transglutaminase 2 Inhibitors as Pharmaceutical Lead Compounds (English)

1 reference

stated in

Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

author name string

Soo-Youl Kim

series ordinal

1

1 reference

stated in

Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

language of work or name

English

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publication date

8 October 2018

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Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

published in

Medical Sciences

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stated in

Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

volume

6

1 reference

stated in

Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

issue

4

1 reference

stated in

Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

copyright license

Creative Commons Attribution 4.0 International

start time

8 October 2018

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stated in

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Catalytic formation of ϵ-(γ-glutamyl)lysine in guinea pig liver transglutaminase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue (type II) transglutaminase covalently incorporates itself, fibrinogen, or fibronectin into high molecular weight complexes on the extracellular surface of isolated hepatocytes. Use of 2-[(2-oxopropyl)thio] imidazolium derivatives as cellular

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of fibrin-derived D-dimer into monomers by endopeptidase from puff adder venom (Bitis arietans) acting at cross-linked sites of the gamma-chain. Sequence of carboxy-terminal cyanogen bromide gamma-chain fragments.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of guinea pig liver transglutaminase. I. Purification and properties of the enzyme: identification of a functional cysteine essential for activity.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of the topology of factor XIIIa-induced fibrin gamma-chain cross-links by electron microscopy of ligated fragments.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forces contributing to the conformational stability of proteins

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of tissue transglutaminase as the autoantigen of celiac disease

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of red sea bream transglutaminase

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted inactivation of Gh/tissue transglutaminase II

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminases in disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of tissue transglutaminase function in the migration of Swiss 3T3 fibroblasts: the active-state conformation of the enzyme does not affect cell motility but is important for its secretion

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminases: crosslinking enzymes with pleiotropic functions

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An enzymically catalyzed incorporation of amines into proteins

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STRUCTURAL REQUIREMENTS OF SPECIFIC SUBSTRATES FOR GUINEA PIG LIVER TRANSGLUTAMINASE

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein-polyamine conjugation by transglutaminase in cancer cell differentiation: review article.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue transglutaminase in normal and abnormal wound healing: review article

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel recognition sequence for fibronectin within the NH2-terminal beta-sandwich domain of tissue transglutaminase

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of tissue transglutaminase in cell-matrix interactions

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase is linked to neurodegenerative diseases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the Solubility of Fibrin Clots

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase 2 undergoes a large conformational change upon activation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological and therapeutic significance of tissue transglutaminase in pancreatic cancer

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transdab wiki: the interactive transglutaminase substrate database on web 2.0 surface

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of human transglutaminase 2 in complex with adenosine triphosphate

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factor XIII: novel structural and functional aspects

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic analysis of high‐molecular‐weight protein polymers in a doxorubicin‐resistant breast‐cancer cell line

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unconventional Secretion of Tissue Transglutaminase Involves Phospholipid-Dependent Delivery into Recycling Endosomes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer cells promote survival through depletion of the von Hippel-Lindau tumor suppressor by protein crosslinking

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Crucial Sequence for Transglutaminase Type 2 Extracellular Trafficking in Renal Tubular Epithelial Cells Lies in Its N-terminal β-Sandwich Domain

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular TG2: emerging functions and regulation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase 2: a new paradigm for NF-kappaB involvement in disease.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue transglutaminase and its role in human cancer progression.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase-2 interaction with heparin: identification of a heparin binding site that regulates cell adhesion to fibronectin-transglutaminase-2 matrix

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase inhibition as a possible therapeutical approach to protect cells from death in neurodegenerative diseases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of transglutaminase 2 drives glycolytic metabolism in renal carcinoma cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of tissue transglutaminase

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase is a tumor cell and cancer stem cell survival factor

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a novel target for renal cell carcinoma: transglutaminase 2.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel regulatory role for tissue transglutaminase in epithelial-mesenchymal transition in cystic fibrosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inter-molecular crosslinking activity is engendered by the dimeric form of transglutaminase 2.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent Progress in the Development of Transglutaminase 2 (TGase2) Inhibitors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nε-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure-Activity Relationships, and Pharmacokinetic Profiling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric inhibition site of transglutaminase 2 is unveiled in the N terminus

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30297644

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.3390/MEDSCI6040087

1 reference

stated in

Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

PMC publication ID

6313797

1 reference

stated in

Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

PubMed publication ID

30297644

1 reference

stated in

Europe PubMed Central

PMC publication ID

6313797

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6313797

 

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