The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression (Q57184205)

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22 January 2020

title

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression (English)

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22 January 2020

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22 January 2020

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22 January 2020

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22 January 2020

Verena Sigl

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22 January 2020

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Daniel Schramek

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Daniel Schramek

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22 January 2020

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Ulrich Elling

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Ulrich Elling

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22 January 2020

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Arabella Meixner

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Arabella Meixner

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22 January 2020

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author name string

Athanassios Kotsinas

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22 January 2020

Teiji Wada

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22 January 2020

J Andrew Pospisilik

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22 January 2020

Ralf-Harun Zwick

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22 January 2020

Guido Forni

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22 January 2020

Vassilis G Gorgoulis

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22 January 2020

language of work or name

English

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publication date

13 February 2011

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22 January 2020

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22 January 2020

volume

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issue

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22 January 2020

page(s)

212-219

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Signal integration by JNK and p38 MAPK pathways in cancer development

22 January 2020

cites work

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Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation

21 January 2018

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Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

21 January 2018

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Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

21 January 2018

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JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

21 January 2018

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MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

21 January 2018

1 reference

The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis

21 January 2018

1 reference

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling

21 January 2018

1 reference

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

21 January 2018

1 reference

Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium

21 January 2018

1 reference

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

21 January 2018

1 reference

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

Tumour biology: senescence in premalignant tumours

21 January 2018

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

21 January 2018

1 reference

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

1 reference

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

21 January 2018

1 reference

Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.

21 January 2018

1 reference

Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

1 reference

Wildtype Kras2 can inhibit lung carcinogenesis in mice

21 January 2018

1 reference

JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

1 reference

Suppression of p53-dependent senescence by the JNK signal transduction pathway

21 January 2018

1 reference

Control of cell cycle progression by c-Jun is p53 dependent

21 January 2018

1 reference

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

21 January 2018

1 reference

JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases

21 January 2018

1 reference

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

21 January 2018

1 reference

Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway

21 January 2018

1 reference

LKB1 modulates lung cancer differentiation and metastasis

21 January 2018

1 reference

21 January 2018

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Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

21 January 2018

1 reference

Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras

21 January 2018

1 reference

Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice.

21 January 2018

1 reference

Cre-mediated gene deletion in the mammary gland

21 January 2018

1 reference

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

21 January 2018

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c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

21 January 2018

1 reference

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

21 January 2018

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Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

21 January 2018

1 reference

Identification and characterization of rodent ABCA1 in isolated type II pneumocytes

21 January 2018

1 reference

The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium

21 January 2018

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The differential effects of mutant p53 alleles on advanced murine lung cancer

21 January 2018

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12 December 2020

p53 mutations in breast cancer

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12 December 2020

Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas

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12 December 2020

Precancerous lesions of the breast

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12 December 2020

Tumour suppression by p53: a role for the DNA damage response?

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12 December 2020

The JNK signal transduction pathway

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12 December 2020

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines

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12 December 2020

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

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12 December 2020

Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.

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12 December 2020

Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

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12 December 2020

Identifiers

DOI

10.1038/NG.767

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22 January 2020

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