Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants (Q57040483)

Olle Melander

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Valeriya Lyssenko

Valeriya Lyssenko

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Leif Groop

Leif Groop

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Bo Isomaa

Bo Isomaa

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Benjamin F. Voight

Benjamin F. Voight

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Peter Almgren

Peter Almgren

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Jasmina Kravic

Jasmina Kravic

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author name string

Lin T. Guey

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Noël P. Burtt

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Jason M. Laramie

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Eero Lindholm

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Peter Nilsson

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Albert B. Seymour

Medical sequencing at the extremes of human body mass

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publication date

2011

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published in

Genetic Epidemiology

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cites work

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Common and rare variants in multifactorial susceptibility to common diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Estimating penetrance from family data using a retrospective likelihood when ascertainment depends on genotype and age of onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Extremely discordant sib-pair study design to determine risk factors for neovascular age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

A new estimate of family disease history providing improved prediction of disease risks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Genome-wide association studies provide new insights into type 2 diabetes aetiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Common variants at 30 loci contribute to polygenic dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Bias and efficiency in family-based gene-characterization studies: conditional, prospective, retrospective, and joint likelihoods

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Power of deep, all-exon resequencing for discovery of human trait genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

The diabetes risk score: a practical tool to predict type 2 diabetes risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Framingham risk score and prediction of lifetime risk for coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Clinical risk factors, DNA variants, and the development of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

A groupwise association test for rare mutations using a weighted sum statistic

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

A strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: a cohort allelic sums test (CAST).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

A note on a general definition of the coefficient of determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

SIFT: Predicting amino acid changes that affect protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Targeted capture and massively parallel sequencing of 12 human exomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Exome sequencing identifies the cause of a mendelian disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Common disorders are quantitative traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Human non-synonymous SNPs: server and survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

The future of genetic studies of complex human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Estimation of genotype relative risks from pedigree data by retrospective likelihoods

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Prediction of deleterious human alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

7 January 2021

The role of extreme phenotype selection studies in the identification of clinically relevant genotypes in cancer research

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

7 January 2021

Extreme discordant sib pairs for mapping quantitative trait loci in humans

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

7 January 2021

Power of selective genotyping in genetic association analyses of quantitative traits

1 reference

https://api.crossref.org/works/10.1002%2FGEPI.20572

7 January 2021