Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 (Q56890058)

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English	Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1	No description defined

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instance of

scholarly article

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title

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 (English)

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main subject

metformin

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based on heuristic

inferred from title

author

Colin A Purdie

series ordinal

16

object named as

Colin A Purdie

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Mien-Chie Hung

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28

object named as

Mien-Chie Hung

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Shih-Shin Chang

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9

object named as

Shih-Shin Chang

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Weiya Xia

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3

object named as

Weiya Xia

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Hung-Ling Wang

series ordinal

12

object named as

Hung-Ling Wang

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Yongkun Wei

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4

object named as

Yongkun Wei

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Heng-Huan Lee

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10

object named as

Heng-Huan Lee

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Chu-Wei Kuo

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13

object named as

Chu-Wei Kuo

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Wen-Hao Yang

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2

object named as

Wen-Hao Yang

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author name string

Jong-Ho Cha

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1

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Li-Chuan Chan

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5

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Seung-Oe Lim

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6

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Chia-Wei Li

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7

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Taewan Kim

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8

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Jennifer L Hsu

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11

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Wei-Chao Chang

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14

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Sirwan Hadad

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15

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Aaron M McCoy

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17

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Shirong Cai

series ordinal

18

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Yizheng Tu

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19

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Jennifer K Litton

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20

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Elizabeth A Mittendorf

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21

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Stacy L Moulder

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22

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William F Symmans

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23

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Alastair M Thompson

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24

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Helen Piwnica-Worms

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25

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Chung-Hsuan Chen

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26

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Kay-Hooi Khoo

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27

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language of work or name

English

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publication date

16 August 2018

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published in

Molecular Cell

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volume

71

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issue

4

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page(s)

606-620.e7

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cites work

Inhibition of endoplasmic reticulum (ER)-to-Golgi transport induces relocalization of binding protein (BiP) within the ER to form the BiP bodies

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Role of AMP-activated protein kinase in mechanism of metformin action

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Expression of Fas ligand is not a main mechanism used by tumors to counteract antitumor immunity

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Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity

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Metformin and reduced risk of cancer in diabetic patients

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Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue

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Effect of glycosylation on protein folding: a close look at thermodynamic stabilization

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AMP-activated protein kinase and human cancer: cancer metabolism revisited

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Role of N-glycosylation in trafficking of apical membrane proteins in epithelia

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One step at a time: endoplasmic reticulum-associated degradation

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PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

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Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.

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Cellular and molecular mechanisms of metformin: an overview

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COPII and the regulation of protein sorting in mammals

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The blockade of immune checkpoints in cancer immunotherapy

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Coinhibitory molecules in autoimmune diseases.

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Comparison of Cytotoxic Activity of Anticancer Drugs against Various Human Tumor Cell Lines Using In Vitro Cell-Based Approach

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Nivolumab plus ipilimumab in advanced melanoma

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N-linked protein glycosylation in the endoplasmic reticulum

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Metformin: an old drug with new potential

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

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Adaptive immune activation: glycosylation does matter

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Metformin--mode of action and clinical implications for diabetes and cancer

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Glycoprotein folding and quality-control mechanisms in protein-folding diseases

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Regulation of Endoplasmic Reticulum-Associated Protein Degradation (ERAD) by Ubiquitin.

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Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma

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PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer

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Immune-mediated antitumor effect by type 2 diabetes drug, metformin

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Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial

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Metformin in breast cancer - an evolving mystery

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Glycosylation-directed quality control of protein folding

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Ipilimumab plus nivolumab for advanced melanoma

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PubMed publication ID

30118680

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