A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients (Q56488761)

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English	A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients	scientific article

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instance of

scholarly article

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title

A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients (English)

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main subject

patient

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prostate cancer

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based on heuristic

inferred from title

pharmacokinetics

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based on heuristic

inferred from title

author name string

Thomas W. Flaig

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1

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Daniel L. Gustafson

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2

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Lih-Jen Su

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3

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Joseph A. Zirrolli

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4

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Frances Crighton

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5

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Gail S. Harrison

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6

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A. Scott Pierson

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7

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Rajesh Agarwal

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8

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L. Michael Glodé

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9

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publication date

1 November 2006

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published in

Investigational New Drugs

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volume

25

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issue

2

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page(s)

139-146

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cites work

Chemopreventive effects of a flavonoid antioxidant silymarin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1007%2FS10637-006-9019-2

retrieved

21 January 2018

Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe CPT-11 toxicity in patients with Gilbert's syndrome: two case reports

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia).

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Milk thistle (Silybum marianum) for the therapy of liver disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of silybin following oral administration of silipide in patients with extrahepatic biliary obstruction

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17077998

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S10637-006-9019-2

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PubMed publication ID

17077998

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