Growth differentiation factor 11 (Q5513076)

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mammalian protein found in Homo sapiens

• GDF11
• BMP-11
• GDF-11
• bone morphogenetic protein 11
• growth/differentiation factor 11

edit

Language	Label	Description	Also known as
English	Growth differentiation factor 11	mammalian protein found in Homo sapiens	GDF11 BMP-11 GDF-11 bone morphogenetic protein 11 growth/differentiation factor 11

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O95390

part of

Transforming growth factor-beta-related

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95390

Cystine-knot cytokine

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95390

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O95390

encoded by

GDF11

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O95390

molecular function

cytokine activity

determination method or standard

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IBA

transforming growth factor beta receptor binding

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IBA

growth factor activity

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

protein binding

determination method or standard

IPI

2 references

retrieved

8 April 2019

stated in

Structural basis for potency differences between GDF8 and GDF11.

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IPI

retrieved

8 April 2019

stated in

Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IPI

cell component

intracellular membrane-bounded organelle

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IDA

nucleoplasm

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IDA

extracellular region

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

extracellular space

determination method or standard

IBA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IBA

cellular component

determination method or standard

ND

1 reference

retrieved

10 September 2018

stated in

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95390&geneProductId=UniProtKB:O95390

determination method or standard

ND

protein-containing complex

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IDA

biological process

regulation of apoptotic process

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IBA

skeletal system development

determination method or standard

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

roof of mouth development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

ureteric bud development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

regulation of MAPK cascade

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IBA

spinal cord anterior/posterior patterning

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

cell development

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IBA

negative regulation of cell differentiation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IBA

cell maturation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

nervous system development

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

TAS

animal organ morphogenesis

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

pancreas development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

mesoderm development

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

TAS

metanephros development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

camera-type eye morphogenesis

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

anterior/posterior pattern specification

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

negative regulation of cell population proliferation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

SMAD protein signal transduction

determination method or standard

IBA

IEA

IMP

3 references

retrieved

8 April 2019

stated in

Structural basis for potency differences between GDF8 and GDF11.

GOA

curator

UniProt

UniProt protein ID

O95390

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IBA

regulation of signaling receptor activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

negative regulation of neuron differentiation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95390

determination method or standard

IEA

has part(s)

Transforming growth factor-beta, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95390

TGF-beta, propeptide

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95390

Transforming growth factor beta, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95390

Identifiers

RefSeq protein ID

NP_005802

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

10220

XP_006719257

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

10220

UniProt protein ID

O95390

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O95390

Ensembl protein ID

ENSP00000257868

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000257868

ENSP00000448390

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000448390

PDB structure ID

5E4G

1 reference

stated in

UniProt

UniProt protein ID

O95390

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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