Implications and challenges of connexin connections to cancer. (Q55052930)

16 June 2018

review article

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title

Implications and challenges of connexin connections to cancer. (English)

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16 June 2018

Dale W Laird

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Christian C Naus

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16 June 2018

language of work or name

English

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publication date

1 June 2010

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16 June 2018

published in

Nature Reviews Cancer

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16 June 2018

volume

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16 June 2018

issue

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16 June 2018

page(s)

435-441

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16 June 2018

Cancer prevention by retinoids and carotenoids: independent action on a common target

cites work

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Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation

21 January 2018

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The CCN3 protein and cancer

21 January 2018

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21 January 2018

12 December 2020

Intercellular Communication and the Control of Tissue Growth: Lack of Communication between Cancer Cells

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31 March 2020

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Gap junction channels: from protein genes to diseases

31 March 2020

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Life cycle of connexins in health and disease

31 March 2020

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Defective gap junctional intercellular communication in the carcinogenic process

31 March 2020

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Gap junctions and cancer: new functions for an old story

31 March 2020

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Intercellular communication and the control of growth: XII. Alteration of junctional permeability by simian virus 40. Roles of the large and small T antigens

31 March 2020

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Intercellular communication and the control of growth: XI. Alteration of junctional permeability by thesrc gene in a revertant cell with normal cytoskeleton

31 March 2020

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Intercellular communication and the control of growth: X. Alteration of junctional permeability by the src gene. A study with temperature-sensitive mutant Rous sarcoma virus

31 March 2020

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Analyzing phorbol ester effects on gap junctional communication: a dramatic inhibition of assembly

31 March 2020

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Chemical, oncogene and growth factor inhibition gap junctional intercellular communication: an integrative hypothesis of carcinogenesis

31 March 2020

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Rapid and reversible reduction of junctional permeability in cells infected with a temperature-sensitive mutant of avian sarcoma virus

31 March 2020

1 reference

Positive selection of candidate tumor-suppressor genes by subtractive hybridization

31 March 2020

1 reference

Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype

31 March 2020

1 reference

Involvement of gap junctions in tumorigenesis: transfection of tumor cells with connexin 32 cDNA retards growth in vivo

31 March 2020

1 reference

Transfection of C6 glioma cells with connexin 43 cDNA: analysis of expression, intercellular coupling, and cell proliferation

31 March 2020

1 reference

Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis

31 March 2020

1 reference

Transfection with different connexin genes alters growth and differentiation of human choriocarcinoma cells

31 March 2020

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High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32

31 March 2020

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The gap junction protein connexin32 is a mouse lung tumor suppressor

31 March 2020

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Mice deficient for the gap junction protein Connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/Erk1, p42/Erk2) activation.

31 March 2020

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Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43.

31 March 2020

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Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver

31 March 2020

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Inhibition of chemically induced neoplastic transformation by carotenoids. Mechanistic studies

31 March 2020

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Retinoid-enhanced gap junctional communication is achieved by increased levels of connexin 43 mRNA and protein

31 March 2020

1 reference

31 March 2020

Connexins and cancer.

1 reference

Reduced number of gap junctions in rat hepatocarcinomas detected by monoclonal antibody

31 March 2020

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The basics of epithelial-mesenchymal transition

31 March 2020

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The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans.

31 March 2020

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Cytoplasmic accumulation of connexin32 protein enhances motility and metastatic ability of human hepatoma cells in vitro and in vivo.

31 March 2020

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Cytoplasmic dye transfer between metastatic tumor cells and vascular endothelium

31 March 2020

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Aberrant expression of connexin 26 is associated with lung metastasis of colorectal cancer.

31 March 2020

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A role for heterologous gap junctions between melanoma and endothelial cells in metastasis

31 March 2020

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Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium

31 March 2020

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Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells.

31 March 2020

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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

31 March 2020

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Selective transfer of endogenous metabolites through gap junctions composed of different connexins

31 March 2020

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Connexin channel permeability to cytoplasmic molecules

31 March 2020

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Astroglial metabolic networks sustain hippocampal synaptic transmission

31 March 2020

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Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers

31 March 2020

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The role of glutathione in cancer.

31 March 2020

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Radiation-induced bystander signalling in cancer therapy

31 March 2020

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Gap junctions: the "kiss of death" and the "kiss of life"

31 March 2020

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Beyond the gap: functions of unpaired connexon channels

31 March 2020

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Functional connexin “hemichannels”: A critical appraisal

31 March 2020

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Gap junction- and hemichannel-independent actions of connexins

31 March 2020

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The gap junction-independent tumor-suppressing effect of connexin 43

31 March 2020

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Dominant-negative abrogation of connexin-mediated cell growth control by mutant connexin genes

31 March 2020

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Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo

31 March 2020

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Mutated connexin43 proteins inhibit rat glioma cell growth suppression mediated by wild-type connexin43 in a dominant-negative manner.

31 March 2020

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The gap junction proteome and its relationship to disease

31 March 2020

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Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes

31 March 2020

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The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1.

31 March 2020

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Caveolin-1 in tumor progression: the good, the bad and the ugly.

31 March 2020

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CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression

31 March 2020

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Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells

31 March 2020

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Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101

31 March 2020

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Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction

31 March 2020

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Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV)

31 March 2020

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Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1).

31 March 2020

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Connexin32 as a tumor suppressor gene in a metastatic renal cell carcinoma cell line

31 March 2020

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Gap junction adhesion is necessary for radial migration in the neocortex

31 March 2020

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Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration.

31 March 2020

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Adhesive properties of connexin hemichannels

31 March 2020

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Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies

31 March 2020

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Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines

31 March 2020

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Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells.

31 March 2020

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Cardiac malformation in neonatal mice lacking connexin43.

31 March 2020

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Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells.

31 March 2020

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Identification of genes that regulate epithelial cell migration using an siRNA screening approach

31 March 2020

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Cellular interaction of integrin alpha3beta1 with laminin 5 promotes gap junctional communication

31 March 2020

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Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells

31 March 2020

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Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation

31 March 2020

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Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27

31 March 2020

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Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation.

31 March 2020

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Gene expression alterations in connexin null mice extend beyond the gap junction.

31 March 2020

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Role for connexin 26 in metastasis of human malignant melanoma: communication between melanoma and endothelial cells via connexin 26.

31 March 2020

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Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture

31 March 2020

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Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer

31 March 2020

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Connexin 32 as an anti-invasive and anti-metastatic gene in renal cell carcinoma

31 March 2020

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Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential

31 March 2020

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The inhibitory effect of connexin 32 gene on metastasis in renal cell carcinoma

31 March 2020

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Malignant proliferating pilar tumors arising in KID syndrome: A report of two patients

31 March 2020

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Altered expression of connexin subtypes in mesial temporal lobe epilepsy in humans

31 March 2020

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Functional contribution of specific brain areas to absence seizures: role of thalamic gap-junctional coupling

31 March 2020

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Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice

31 March 2020

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Induction of skin papillomas, carcinomas, and sarcomas in mice in which the connexin 43 gene is heterologously deleted

31 March 2020

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Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32-deficient mice

31 March 2020

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The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains

31 March 2020

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Hepatocarcinogenesis in female mice with mosaic expression of connexin32

31 March 2020

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Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner

31 March 2020

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Targeted epidermal expression of mutant Connexin 26(D66H) mimics true Vohwinkel syndrome and provides a model for the pathogenesis of dominant connexin disorders

31 March 2020

1 reference

A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia

31 March 2020

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Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia.

31 March 2020

1 reference

Dislocation and degradation from the ER are regulated by cytosolic stress

31 March 2020

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Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER

31 March 2020

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Gap junction protein connexin-43 interacts directly with microtubules

31 March 2020

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Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions

31 March 2020

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Analysis of gap junctions and formation plaques between reaggregating Novikoff hepatoma cells

31 March 2020

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The gap junction cellular internet: connexin hemichannels enter the signalling limelight

31 March 2020

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Connexins and gap junctions in mammary gland development and breast cancer progression

31 March 2020

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Negative growth control of HeLa cells by connexin genes: connexin species specificity.

31 March 2020

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12 December 2020

Inhibition of Src activity enhances the tumor-suppressive effect of the connexin 32 gene in Caki-1 renal cancer cells.

1 reference

12 December 2020

Proteomic analysis of astroglial connexin43 silencing uncovers a cytoskeletal platform involved in process formation and migration

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12 December 2020

Connexin 26 induces growth suppression, apoptosis and increased efficacy of doxorubicin in prostate cancer cells

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12 December 2020

Defective vascular development in connexin 45-deficient mice

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12 December 2020

Deficiency of connexin43 gap junctions is an independent marker for breast tumors

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12 December 2020

Clinical phenotype and mutations in connexin 26 (DFNB1/GJB2), the most common cause of childhood hearing loss

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12 December 2020

Emerging role of gap junctions in epilepsy

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12 December 2020

Growth inhibition by connexin26 expression in cultured rodent tumor cells.

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12 December 2020

The cell-cell channel in the control of growth

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12 December 2020

Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases

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12 December 2020

Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication.

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12 December 2020

Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43).

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12 December 2020

Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential.

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12 December 2020

Identifiers

DOI

10.1038/NRC2841

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16 June 2018

Dimensions Publication ID

1053731767

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16 June 2018