Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia. (Q55042990)

16 June 2018

title

Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia. (English)

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16 June 2018

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16 June 2018

Sabine Strehl

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16 June 2018

Theodor Dingermann

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16 June 2018

Rolf Marschalek

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16 June 2018

author name string

Meyer C

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16 June 2018

Schneider B

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16 June 2018

Hubert D

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16 June 2018

Zach O

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16 June 2018

Haas O

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16 June 2018

Klingebiel T

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16 June 2018

publication date

25 January 2007

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16 June 2018

published in

Leukemia

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16 June 2018

volume

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16 June 2018

issue

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16 June 2018

page(s)

588-590

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16 June 2018

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

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Secondary acute leukemia and myelodysplastic syndrome with 11q23 abnormalities. EU Concerted Action 11q23 Workshop

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The MLL recombinome of acute leukemias

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The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis.

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7 January 2021

MLL/ENL fusion in congenital acute lymphoblastic leukemia with a unique t(11;18;19).

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Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia

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7 January 2021

Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation

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7 January 2021

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs

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7 January 2021

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

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7 January 2021

The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell

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7 January 2021

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer

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7 January 2021

Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis

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7 January 2021

Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells

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7 January 2021

Diagnostic tool for the identification of MLL rearrangements including unknown partner genes

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7 January 2021

Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation

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7 January 2021

Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells

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7 January 2021

A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15.

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2404542

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16 June 2018

Dimensions Publication ID

1010088661

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16 June 2018