Anticancer Properties of Fenofibrate: A Repurposing Use. (Q55021652)

15 June 2018

title

Anticancer Properties of Fenofibrate: A Repurposing Use. (English)

1 reference

15 June 2018

author name string

Xin Lian

1 reference

15 June 2018

Gang Wang

1 reference

15 June 2018

Honglan Zhou

1 reference

15 June 2018

Zongyu Zheng

1 reference

15 June 2018

Yaowen Fu

1 reference

15 June 2018

Lu Cai

1 reference

15 June 2018

publication date

6 April 2018

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15 June 2018

published in

Journal of Cancer

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15 June 2018

volume

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15 June 2018

issue

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15 June 2018

page(s)

1527-1537

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15 June 2018

In Vitro Apoptosis Induction by Fenofibrate in Lymphoma and Multiple Myeloma

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Fenofibrate suppressed proliferation and migration of human neuroblastoma cells via oxidative stress dependent of TXNIP upregulation

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Fenofibrate induces G0/G1 phase arrest by modulating the PPARα/FoxO1/p27 kip pathway in human glioblastoma cells

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AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-κB pathway

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Fenofibrate enhances barrier function of endothelial continuum within the metastatic niche of prostate cancer cells.

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16 June 2018

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Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells

16 June 2018

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An update on the molecular actions of fenofibrate and its clinical effects on diabetic retinopathy and other microvascular end points in patients with diabetes

16 June 2018

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Thioredoxin interacting protein and its association with clinical outcome in gastro-oesophageal adenocarcinoma

16 June 2018

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Fenofibrate suppresses melanogenesis in B16-F10 melanoma cells via activation of the p38 mitogen-activated protein kinase pathway

16 June 2018

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Fenofibrate down-regulates the expressions of androgen receptor (AR) and AR target genes and induces oxidative stress in the prostate cancer cell line LNCaP.

16 June 2018

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Long noncoding RNAs in cardiac development and pathophysiology

16 June 2018

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Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models

16 June 2018

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Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro.

16 June 2018

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Involvement of long noncoding RNAs in diseases affecting the central nervous system

16 June 2018

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mTOR signaling in growth control and disease

16 June 2018

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The prognostic and predictive power of redox protein expression for anthracycline-based chemotherapy response in locally advanced breast cancer

16 June 2018

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Fenofibric acid for hyperlipidemia

16 June 2018

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16 June 2018

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The PPARα agonists fenofibrate and CP-778875 cause increased β-oxidation, leading to oxidative injury in skeletal and cardiac muscle in the rat.

16 June 2018

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Role of the PPAR-α agonist fenofibrate in severe pediatric burn

16 June 2018

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Fenofibrate: a review of its lipid-modifying effects in dyslipidemia and its vascular effects in type 2 diabetes mellitus

16 June 2018

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Fenofibrate attenuates contact-stimulated cell motility and gap junctional coupling in DU-145 human prostate cancer cell populations

16 June 2018

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Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms

16 June 2018

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Lipids, lipid-lowering therapy and diabetes complications

16 June 2018

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Pleiotropic actions of fenofibrate on the heart

16 June 2018

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ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis

16 June 2018

1 reference

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Plasticity of cell migration: a multiscale tuning model

16 June 2018

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16 June 2018

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

16 June 2018

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Unravelling the tumor-suppressive functions of FOXO proteins

16 June 2018

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Anticancer Properties of PPARalpha-Effects on Cellular Metabolism and Inflammation

16 June 2018

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PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition.

16 June 2018

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Androgen signaling and its interactions with other signaling pathways in prostate cancer

16 June 2018

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Peroxisome proliferator-activated receptor alpha and gamma ligands inhibit the growth of human ovarian cancer

16 June 2018

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PPARalpha and PP2A are involved in the proapoptotic effect of conjugated linoleic acid on human hepatoma cell line SK-HEP-1.

16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt.

16 June 2018

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In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer

16 June 2018

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Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells

16 June 2018

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Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism

16 June 2018

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Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18.

16 June 2018

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Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner

16 June 2018

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Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands

16 June 2018

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Transcriptome analysis of endometrial cancer identifies peroxisome proliferator-activated receptors as potential therapeutic targets

16 June 2018

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The human semaphorin 6B gene is down regulated by PPARs.

16 June 2018

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Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells

16 June 2018

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Cytotoxic effect of peroxisome proliferator fenofibrate on human HepG2 hepatoma cell line and relevant mechanisms.

16 June 2018

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Multiple myeloma: evolving genetic events and host interactions

16 June 2018

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Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation

16 June 2018

1 reference

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The mechanisms of action of PPARs

16 June 2018

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Lipid-lowering therapy in diabetes mellitus

16 June 2018

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The PPARs: from orphan receptors to drug discovery

16 June 2018

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Mechanism of action of fibrates on lipid and lipoprotein metabolism

16 June 2018

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Regulation of apo A-I gene expression by fibrates

16 June 2018

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Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines

16 June 2018

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Micronised fenofibrate: a review of its pharmacodynamic properties and clinical efficacy in the management of dyslipidaemia

16 June 2018

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PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene

16 June 2018

1 reference

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Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

16 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice

16 June 2018

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The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules

16 June 2018

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Hepatic peroxisome proliferation in rodents and its significance for humans

16 June 2018

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Fenofibrate: Metabolism and Species Differences for Peroxisome Proliferation in Cultured Hepatocytes

16 June 2018

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

Modulation of lipoprotein production in hep G2 cells by fenofibrate and clofibrate

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

Differential effects on lung cancer cell proliferation by agonists of glucocorticoid and PPARα receptors

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11beta-HSD1, PEPCK and DGAT2. Comparison of PPARalpha, PPARgamma, and liver x receptor agonists

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

Mechanisms of the triglyceride- and cholesterol-lowering effect of fenofibrate in hyperlipidemic type 2 diabetic patients

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5950581

13 August 2018

Endometrial carcinoma

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12 December 2020

Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences

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12 December 2020

Bezafibrate as differentiating factor of human myeloid leukemia cells

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12 December 2020

[Present status of fibrates in the treatment of hyperlipoproteinemias]

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12 December 2020

Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model

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12 December 2020

Fenofibrate-induced massive regression of mutiple inflammatory hepatocellular adenoma

1 reference

12 December 2020

Identifiers

DOI

10.7150/JCA.24488

1 reference

15 June 2018

PMC publication ID

5950581

1 reference

15 June 2018

PubMed publication ID

29760790

1 reference

15 June 2018