The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia (Q54385532)

29 May 2018

https://api.crossref.org/works/10.1038/LEU.2010.322

title

The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia (English)

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25 November 2024

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1 reference

J. Dürig

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U. Dührsen

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L. Klein-Hitpass

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J. Worm

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J. B Rode Hansen

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H. Ørum

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M. Wissenbach

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25 November 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21358717

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publication date

1 March 2011

1 reference

29 May 2018

full work available at URL

https://www.nature.com/articles/leu2010322.pdf

file format

Portable Document Format

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21358717

https://www.nature.com/articles/leu2010322.pdf

25 November 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/LEU.2010.322

https://www.nature.com/articles/leu2010322

25 November 2024

1 reference

https://api.crossref.org/works/10.1038/LEU.2010.322

25 November 2024

1 reference

29 May 2018

volume

1 reference

29 May 2018

issue

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29 May 2018

page(s)

638-647

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29 May 2018

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

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Bcl-2 and apoptosis in chronic lymphocytic leukemia

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Bcl-2 antisense therapy in B-cell malignancies

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Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia

21 January 2018

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5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen

21 January 2018

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Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia.

21 January 2018

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Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy

21 January 2018

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The combination of the proteasome inhibitor bortezomib and the bcl-2 antisense molecule oblimersen sensitizes human B-cell lymphomas to cyclophosphamide

21 January 2018

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Modulation of CpG oligodeoxynucleotide-mediated immune stimulation by locked nucleic acid (LNA).

21 January 2018

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Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

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Locked nucleic acid as a novel class of therapeutic agents

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Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status.

21 January 2018

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Efficient nucleofection of primary human B cells and B-CLL cells induces apoptosis, which depends on the microenvironment and on the structure of transfected nucleic acids

21 January 2018

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Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma

21 January 2018

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CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells

21 January 2018

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In vitro and in vivo activation induces BAFF and APRIL expression in B cells.

21 January 2018

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CpG drives human transitional B cells to terminal differentiation and production of natural antibodies

21 January 2018

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Phase I study of bortezomib with weekly paclitaxel in patients with advanced solid tumours.

21 January 2018

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Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response

21 January 2018

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Isolation of microarray-grade total RNA, microRNA, and DNA from a single PAXgene blood RNA tube

21 January 2018

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Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells.

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G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice

21 January 2018

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Expression and function of toll like receptors in chronic lymphocytic leukaemia cells.

21 January 2018

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Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation

21 January 2018

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Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells

21 January 2018

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A phase I/II trial of TLR-7 agonist immunotherapy in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.322

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7 January 2021

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A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease

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7 January 2021

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Identifiers

DOI

10.1038/LEU.2010.322

1 reference

29 May 2018

1 reference

29 May 2018