LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. (Q54348800)

28 May 2018

title

LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. (English)

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28 May 2018

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Tsung-Ying He

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28 May 2018

Lung-Hung Tsai

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28 May 2018

Chi-Chou Huang

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28 May 2018

Ming-Chih Chou

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28 May 2018

Huei Lee

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28 May 2018

publication date

31 May 2014

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28 May 2018

Annals of Surgical Oncology

published in

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28 May 2018

volume

21 Suppl 4

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28 May 2018

page(s)

S703-10

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28 May 2018

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

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A De Novo mutation of STK11 gene in a Chinese patient with Peutz-Jeghers syndrome.

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Analysis of STK11 gene variant in five Chinese patients with Peutz-Jeghers syndrome

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LKB1 somatic mutations in sporadic tumors

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5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer

21 January 2018

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An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers

21 January 2018

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Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy

21 January 2018

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Mutations in the human LKB1/STK11 gene

21 January 2018

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Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion.

21 January 2018

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LKB1 modulates lung cancer differentiation and metastasis

21 January 2018

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LKB1 catalytically deficient mutants enhance cyclin D1 expression.

21 January 2018

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The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss

21 January 2018

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LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

21 January 2018

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LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer.

21 January 2018

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Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo

21 January 2018

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LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

21 January 2018

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LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

21 January 2018

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A novel p53 mutant retained functional activity in lung carcinomas.

21 January 2018

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Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression

21 January 2018

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DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer

21 January 2018

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Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer.

21 January 2018

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Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

21 January 2018

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The coordinate regulation of the p53 and mTOR pathways in cells

21 January 2018

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The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

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LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins

21 January 2018

1 reference

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10.1245/S10434-014-3824-1

21 January 2018

Identifiers

DOI

1 reference

28 May 2018

Dimensions Publication ID

1027895080

0 references

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28 May 2018