GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet. (Q43970874)

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scientific article published in October 2013

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English	GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet.	scientific article published in October 2013

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28 February 2020

GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet (English)

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28 February 2020

insulin resistance

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Bernhard Bettler

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Bernhard Bettler

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28 February 2020

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Yoshihiro Ito

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28 February 2020

Ryoichi Banno

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Miyuki Shibata

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28 February 2020

Koichi Adachi

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Shigeru Hagimoto

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28 February 2020

Daisuke Hagiwara

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28 February 2020

Yoshiharu Ozawa

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28 February 2020

Motomitsu Goto

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Hidetaka Suga

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28 February 2020

Yoshihisa Sugimura

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28 February 2020

Yutaka Oiso

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28 February 2020

Hiroshi Arima

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1 October 2013

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28 February 2020

Journal of Neuroscience

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28 February 2020

17166-17173

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28 February 2020

describes a project that uses

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Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

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https://pubmed.ncbi.nlm.nih.gov/24155320

12 December 2020

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Central nervous system control of food intake

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Pathophysiological role of leptin in obesity-related hypertension.

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Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

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https://pubmed.ncbi.nlm.nih.gov/24155320

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Central melanocortin receptors regulate insulin action

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Melanocortin receptor agonist transiently increases oxygen consumption in rats

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β-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R?

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Rapid rewiring of arcuate nucleus feeding circuits by leptin.

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Proopiomelanocortin and energy balance: insights from human and murine genetics

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Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

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Floxed allele for conditional inactivation of the GABAB(1) gene

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https://pubmed.ncbi.nlm.nih.gov/24155320

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Characterization of leptin-responsive neurons in the caudal brainstem

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https://pubmed.ncbi.nlm.nih.gov/24155320

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Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

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https://pubmed.ncbi.nlm.nih.gov/24155320

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Central nervous system control of food intake and body weight

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https://pubmed.ncbi.nlm.nih.gov/24155320

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Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding

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https://pubmed.ncbi.nlm.nih.gov/24155320

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Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

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GABAB receptors and glucose homeostasis: evaluation in GABAB receptor knockout mice

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Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

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Positive Effect of Baclofen on Body Weight Reduction in Obese Subjects: A Pilot Study

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Regulation of GABA and glutamate release from proopiomelanocortin neuron terminals in intact hypothalamic networks

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https://pubmed.ncbi.nlm.nih.gov/24155320

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Expression of GABAergic and glutamatergic phenotypic markers in hypothalamic proopiomelanocortin neurons

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Regulation of neuronal GABA(B) receptor functions by subunit composition

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Identifiers

10.1523/JNEUROSCI.0897-13.2013

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28 February 2020

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28 February 2020

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28 February 2020

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