Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function (Q43930617)

28 November 2017

title

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function (English)

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28 November 2017

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28 November 2017

Muriel Laffargue

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Matthias P Wymann

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Ronan Calvez

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28 November 2017

Peter Finan

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28 November 2017

Alexandre Trifilieff

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28 November 2017

Maryse Barbier

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28 November 2017

Fiorella Altruda

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28 November 2017

language of work or name

English

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publication date

1 March 2002

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28 November 2017

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28 November 2017

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28 November 2017

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28 November 2017

page(s)

441-451

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Macrophage inflammatory protein-1 alpha activates basophils and mast cells

28 November 2017

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

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Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking

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7 January 2021

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI)

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Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2.

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Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation

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7 January 2021

Phosphoinositide 3-kinase facilitates antigen-stimulated Ca(2+) influx in RBL-2H3 mast cells via a phosphatidylinositol 3,4,5-trisphosphate-sensitive Ca(2+) entry mechanism

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Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene

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Adenosine, mast cells and asthma

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A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis.

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Chemokines and disease

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7 January 2021

Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

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Monocyte chemoattractant peptide-1 expression during cutaneous allergic reactions in mice is mast cell dependent and largely mediates the monocyte recruitment response

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7 January 2021

High-affinity IgE receptor on eosinophils is involved in defence against parasites

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7 January 2021

Essential role for Gab2 in the allergic response

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7 January 2021

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

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7 January 2021

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation

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7 January 2021

Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells.

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7 January 2021

Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism

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7 January 2021

The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor

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7 January 2021

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

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7 January 2021

Evidence that IgE receptor stimulation increases adenosine release from rat basophilic leukaemia (RBL-2H3) cells

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7 January 2021

Chemokines--chemotactic cytokines that mediate inflammation

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7 January 2021

Role of the monocyte chemoattractant protein and eotaxin subfamily of chemokines in allergic inflammation

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7 January 2021

Alteration of mast cell responsiveness to adenosine by pertussis toxin

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7 January 2021

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7 January 2021

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.

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7 January 2021

The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation

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7 January 2021

Chemokine receptors in airway disease: which receptors to target?

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7 January 2021

Differential interaction with and regulation of multiple G-proteins by the rat A3 adenosine receptor

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7 January 2021

The strategy of blocking the chemokine system to combat disease

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7 January 2021

LAT is essential for Fc(epsilon)RI-mediated mast cell activation

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7 January 2021

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

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7 January 2021

PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals

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7 January 2021

p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production.

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7 January 2021

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

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7 January 2021

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

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7 January 2021

Effects of wortmannin on bronchoconstrictor responses to adenosine in actively sensitised Brown Norway rats

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7 January 2021

Adenosine and inosine increase cutaneous vasopermeability by activating A(3) receptors on mast cells

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7 January 2021

Signalling through the high-affinity IgE receptor Fc epsilonRI.

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7 January 2021

High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.

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7 January 2021

Structure and function of phosphoinositide 3-kinases.

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7 January 2021

Interleukin 8 and mast cell-generated tumor necrosis factor-alpha in neutrophil recruitment

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7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

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7 January 2021

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor

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7 January 2021

10.1016/S1074-7613(02)00282-0

Identifiers

DOI

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28 November 2017

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