Human cationic trypsinogen. Arg(117) is the reactive site of an inhibitory surface loop that controls spontaneous zymogen activation. (Q43826802)

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5 December 2019

title

Human cationic trypsinogen. Arg(117) is the reactive site of an inhibitory surface loop that controls spontaneous zymogen activation (English)

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5 December 2019

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5 December 2019

Zoltán Kukor

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5 December 2019

Miklós Tóth

series ordinal

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5 December 2019

Miklós Sahin-Tóth

series ordinal

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5 December 2019

language of work or name

English

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publication date

17 December 2001

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Journal of Biological Chemistry

5 December 2019

published in

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5 December 2019

volume

277

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5 December 2019

issue

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5 December 2019

page(s)

6111-6117

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Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

5 December 2019

cites work

1 reference

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Discrimination of three mutational events that result in a disruption of the R122 primary autolysis site of the human cationic trypsinogen (PRSS1) by denaturing high performance liquid chromatography

21 January 2018

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Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis

21 January 2018

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Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis

21 January 2018

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Mutations of the cationic trypsinogen in hereditary pancreatitis

21 January 2018

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A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis

21 January 2018

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Mutational screening of the cationic trypsinogen gene in a large cohort of subjects with idiopathic chronic pancreatitis

21 January 2018

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Two mutations in rat trypsin confer resistance against autolysis.

21 January 2018

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Hereditary pancreatitis-associated mutation asn(21) --> ile stabilizes rat trypsinogen in vitro

21 January 2018

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Trypsinogen stabilization by mutation Arg117-->His: a unifying pathomechanism for hereditary pancreatitis?

21 January 2018

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High-affinity Ca(2+) binding inhibits autoactivation of rat trypsinogen

21 January 2018

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Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitis

21 January 2018

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Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen

21 January 2018

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The pathobiochemistry of hereditary pancreatitis: studies on recombinant human cationic trypsinogen.

21 January 2018

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Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis.

21 January 2018

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Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

21 January 2018

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What can the structures of enzyme-inhibitor complexes tell us about the structures of enzyme substrate complexes?

21 January 2018

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Wanted: a consensus nomenclature for cationic trypsinogen mutations.

21 January 2018

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Characterization of active derivatives produced by acetamidination and selective autolysis of bovine trypsin

21 January 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

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Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151

21 January 2018

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Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations

21 January 2018

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Synthesis of peptide bonds by proteinases. Addition of organic cosolvents shifts peptide bond equilibriums toward synthesis

21 January 2018

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Natural protein proteinase inhibitors and their interaction with proteinases

21 January 2018

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Trypsinogen variants in pancreatic juice of healthy volunteers, chronic alcoholics, and patients with pancreatitis and cancer of the pancreas

21 January 2018

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The protein content and morphogenesis of zymogen granules

21 January 2018

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Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation

21 January 2018

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Hereditary pancreatitis in North America: the Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study

21 January 2018

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The A16V signal peptide cleavage site mutation in the cationic trypsinogen gene and chronic pancreatitis

21 January 2018

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Trypsinogen mutations in chronic pancreatitis

21 January 2018

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Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation

21 January 2018

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Identification of a novel pancreatitis-associated missense mutation, R116C, in the human cationic trypsinogen gene (PRSS1)

21 January 2018

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The identification of neotrypsinogens in samples of bovine trypsinogen

21 January 2018

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On some autolyzed derivatives of bovine trypsin

21 January 2018

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Dermasterias imbricata trypsin 1: an enzyme which rapidly hydrolyzes the reactive-site peptide bonds of protein trypsin inhibitors

21 January 2018

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Trypsin complexed with α1‐proteinase inhibitor has an increased structural flexibility

21 January 2018

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Enzymatic condensation of nonassociated peptide fragments using a molecular trap

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M110959200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11748242%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

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