Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells (Q43630489)

25 November 2017

title

Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells (English)

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25 November 2017

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K M McMasters

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25 November 2017

H L Yang

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25 November 2017

Y B Dong

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25 November 2017

M J Elliott

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25 November 2017

S L Wong

series ordinal

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25 November 2017

publication date

1 April 2001

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25 November 2017

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25 November 2017

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25 November 2017

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25 November 2017

page(s)

241-251

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Osteosarcoma and other tumors of bone

25 November 2017

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Mapping of the p53 and mdm-2 Interaction Domains

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

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Mdm2 promotes the rapid degradation of p53

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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7 January 2021

Interaction between the retinoblastoma protein and the oncoprotein MDM2

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Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

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7 January 2021

The regulation of E2F by pRB-family proteins

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Oncogenic capacity of the E2F1 gene

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Multiple members of the E2F transcription factor family are the products of oncogenes

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7 January 2021

Regulation of cell proliferation by the E2F transcription factors

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7 January 2021

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

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7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

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7 January 2021

E2F-1 functions in mice to promote apoptosis and suppress proliferation

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7 January 2021

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors

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Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

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7 January 2021

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

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7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

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7 January 2021

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

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7 January 2021

The transcription factor E2F-1 is a downstream target of RB action

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7 January 2021

E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis

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7 January 2021

Edatrexate in patients with soft tissue sarcoma. Activity in malignant fibrous histiocytoma

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Adjuvant chemotherapy with doxorubicin in high-grade soft tissue sarcoma: a randomized trial of the Scandinavian Sarcoma Group

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Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic arteries, and two models of coronary restenosis

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7 January 2021

Genetic determinants of p53-induced apoptosis and growth arrest

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7 January 2021

Manipulation of Adenovirus Vectors

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7 January 2021

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

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7 January 2021

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

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7 January 2021

Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells

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7 January 2021

Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

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7 January 2021

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

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7 January 2021

Topoisomerases II alpha and beta as therapy targets in breast cancer.

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7 January 2021

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

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7 January 2021

Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases

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7 January 2021

A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells

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7 January 2021

Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis

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7 January 2021

E2F-1-induced p53-independent apoptosis in transgenic mice.

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7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700301

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Dimensions Publication ID

25 November 2017

1047382928

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