Molecular genetics and structural biology of human MutT homolog, MTH1. (Q43619841)

25 November 2017

title

Molecular genetics and structural biology of human MutT homolog, MTH1. (English)

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25 November 2017

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Y Nakabeppu

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25 November 2017

language of work or name

English

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publication date

1 June 2001

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25 November 2017

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25 November 2017

volume

477

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25 November 2017

issue

1-2

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25 November 2017

page(s)

59-70

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Endogenous mutagens and the causes of aging and cancer

25 November 2017

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Oxidants, antioxidants, and the degenerative diseases of aging

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MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

7 January 2021

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7 January 2021

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The unusual mutagenic specificity of an E. Coli mutator gene

7 January 2021

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A specific role of MutT protein: to prevent dG.dA mispairing in DNA replication

7 January 2021

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Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli

7 January 2021

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Counteraction by MutT protein of transcriptional errors caused by oxidative damage.

7 January 2021

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Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool

7 January 2021

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Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion

7 January 2021

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Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products

7 January 2021

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Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: evidence of persistent oxidative stress in cancer

7 January 2021

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Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells

7 January 2021

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Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism

7 January 2021

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Organization and expression of the mouse MTH1 gene for preventing transversion mutation

7 January 2021

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Redox regulation of genes that protect against carcinogens

7 January 2021

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Sequence and characterization of mutT from Proteus vulgaris

7 January 2021

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Characterization of the mutX gene of Streptococcus pneumoniae as a homologue of Escherichia coli mutT, and tentative definition of a catalytic domain of the dGTP pyrophosphohydrolases

7 January 2021

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The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymes

7 January 2021

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Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution

7 January 2021

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cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides

7 January 2021

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The role of Glu 57 in the mechanism of the Escherichia coli MutT enzyme by mutagenesis and heteronuclear NMR.

7 January 2021

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Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action

7 January 2021

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Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. Cloning, purification, and characterization of the enzyme.

7 January 2021

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Orf186 Represents a New Member of the Nudix Hydrolases, Active on Adenosine(5′)triphospho(5′)adenosine, ADP-ribose, and NADH

7 January 2021

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7 January 2021

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Identification and characterization of the Nudix hydrolase from the Archaeon, Methanococcus jannaschii, as a highly specific ADP-ribose pyrophosphatase

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A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase

7 January 2021

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Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins

7 January 2021

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Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.

7 January 2021

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Significance of the conserved amino acid sequence for human MTH1 protein with antimutator activity

7 January 2021

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Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II).

7 January 2021

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Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase

7 January 2021

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The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

7 January 2021

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Metabolic fate of oxidized guanine ribonucleotides in mammalian cells

7 January 2021

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The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase

7 January 2021

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Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

7 January 2021

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Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

7 January 2021

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Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria

7 January 2021

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Computational method to predict mitochondrially imported proteins and their targeting sequences

7 January 2021

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Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer.

7 January 2021

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Generation and elimination of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate, a mutagenic substrate for DNA synthesis, in human cells

7 January 2021

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10.1016/S0027-5107(01)00096-3

7 January 2021

Identifiers

DOI

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25 November 2017

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