The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop (Q43590670)

25 November 2017

title

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop (English)

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25 November 2017

Zhou A

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25 November 2017

Carrell RW

series ordinal

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25 November 2017

Huntington JA

series ordinal

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25 November 2017

language of work or name

English

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publication date

26 April 2001

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Journal of Biological Chemistry

25 November 2017

published in

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25 November 2017

volume

276

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25 November 2017

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25 November 2017

page(s)

27541-27547

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What can the structures of enzyme-inhibitor complexes tell us about the structures of enzyme substrate complexes?

25 November 2017

cites work

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A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism

21 January 2018

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Structure of a serpin-protease complex shows inhibition by deformation

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Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases

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Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder

21 January 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

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Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.

21 January 2018

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The P6−P2 Region of Serpins Is Critical for Proteinase Inhibition and Complex Stability

21 January 2018

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Serpin conformational change in ovalbumin. Enhanced reactive center loop insertion through hinge region mutations

21 January 2018

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On the size of the active site in proteases. I. Papain

21 January 2018

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Structural basis of the activation and action of trypsin

21 January 2018

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Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

21 January 2018

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Trypsin complexed with α1‐proteinase inhibitor has an increased structural flexibility

21 January 2018

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Apparent formation of sodium dodecyl sulfate-stable complexes between serpins and 3,4-dichloroisocoumarin-inactivated proteinases is due to regeneration of active proteinase from the inactivated enzyme

21 January 2018

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Protein engineering of chimeric Serpins: an investigation into effects of the serpin scaffold and reactive centre loop length

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M102594200

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25 November 2017

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