The coupling of tight DNA binding and base flipping: identification of a conserved structural motif in base flipping enzymes (Q43409472)

23 November 2017

title

The coupling of tight DNA binding and base flipping: identification of a conserved structural motif in base flipping enzymes (English)

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23 November 2017

R August Estabrook

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23 November 2017

Rebecca Lipson

series ordinal

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23 November 2017

Ben Hopkins

series ordinal

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23 November 2017

Norbert Reich

series ordinal

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23 November 2017

language of work or name

English

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publication date

12 May 2004

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Journal of Biological Chemistry

23 November 2017

published in

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23 November 2017

volume

279

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23 November 2017

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23 November 2017

page(s)

31419-31428

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A perspective on enzyme catalysis.

23 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

A view at the millennium: the efficiency of enzymatic catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

The time scale of the catalytic loop motion in triosephosphate isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

A new conceptual framework for enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Enzyme dynamics during catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Active site dynamics of the HhaI methyltransferase: insights from computer simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

The mechanism of DNA cytosine-5 methylation. Kinetic and mutational dissection of Hhai methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

M.HhaI binds tightly to substrates containing mismatches at the target base

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Functional analysis of Gln-237 mutants of HhaI methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic center

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Mutational analysis of conserved residues in HhaI DNA methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

HhaI methyltransferase flips its target base out of the DNA helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Purification, crystallization, and preliminary X-ray diffraction analysis of an M.HhaI-AdoMet complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

The thymidylate synthesis cycle and anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Cancer epigenetics comes of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

The role of DNA methylation in mammalian epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

DNA methylation: past, present and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

A base-flipping mechanism for the T4 phage beta-glucosyltransferase and identification of a transition-state analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Presteady-state analysis of a single catalytic turnover by Escherichia coli uracil-DNA glycosylase reveals a "pinch-pull-push" mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Free energy and structural pathways of base flipping in a DNA GCGC containing sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Dynamic modes of the flipped-out cytosine during HhaI methyltransferase-DNA interactions in solution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

DNA bending by EcoRI DNA methyltransferase accelerates base flipping but compromises specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Direct Real Time Observation of Base Flipping by theEcoRI DNA Methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

A general method for the purification of restriction enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Kinetic mechanism of the EcoRI DNA methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Nonenzymatic Deamidation of Asparaginyl and Glutaminyl Residues in Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Deamidation of labile asparagine residues in the autoregulatory sequence of human phenylalanine hydroxylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Cytosine methyltransferase from Escherichia coli in which active site cysteine is replaced with serine is partially active

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

A Taq attack displaces bases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Structure and Function of DNA Methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Dynamics of mismatched base pairs in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

Use of Oligodeoxyribonucleotides with Conformationally Constrained Abasic Sugar Targets To Probe the Mechanism of Base Flipping byHhaI DNA (Cytosine C5)-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402950200

21 January 2018

Identifiers

DOI

10.1074/JBC.M402950200

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23 November 2017

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