Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-a (Q43272233)

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scientific article published on 24 September 2009

Language	Label	Description	Also known as
English	Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-a	scientific article published on 24 September 2009

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-a (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

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based on heuristic

inferred from title

author name string

Subhasree Roy Choudhury

1

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

Surajit Karmakar

2

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Europe PubMed Central

PubMed publication ID

18 November 2017

Naren L Banik

3

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

Swapan K Ray

4

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

publication date

24 September 2009

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Europe PubMed Central

PubMed publication ID

18 November 2017

Investigational New Drugs

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Europe PubMed Central

PubMed publication ID

18 November 2017

28

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Europe PubMed Central

PubMed publication ID

18 November 2017

6

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Europe PubMed Central

PubMed publication ID

18 November 2017

812-824

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Europe PubMed Central

PubMed publication ID

18 November 2017

Proliferation and hTERT expression in neuroblastoma

1 reference

https://api.crossref.org/works/10.1007%2FS10637-009-9324-7

21 January 2018

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

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Angiogenesis in neuroblastoma.

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https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

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Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoids induce differentiation and downregulate telomerase activity and N-Myc to increase sensitivity to flavonoids for apoptosis in human malignant neuroblastoma SH-SY5Y cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein modulates neuroblastoma cell proliferation and differentiation through induction of apoptosis and regulation of tyrosine kinase activity and N-myc expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein induces apoptosis in ovarian cancer cells via different molecular pathways depending on Breast Cancer Susceptibility gene-1 (BRCA1) status

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospects for therapeutic inhibition of neuroblastoma angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor blockade rapidly elicits alternative proangiogenic pathways in neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effectiveness of screening for neuroblastoma at 6 months of age: a retrospective population-based cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel atypical retinoid ST1926 is active in ATRA resistant neuroblastoma cells acting by a different mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor cell-associated neuropilin-1 and vascular endothelial growth factor expression as determinants of tumor growth in neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Inhibitors for protein tyrosine kinases, erbstatin, genistein and herbimycin A, induce differentiation of human neural tumor cell lines]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of calpain and caspase-3 prevented apoptosis and preserved electrophysiological properties of voltage-gated and ligand-gated ion channels in rat primary cortical neurons exposed to glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein induces Ca2+ -mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doenjang hexane fraction-induced G1 arrest is associated with the inhibition of pRB phosphorylation and induction of Cdk inhibitor p21 in human breast carcinoma MCF-7 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Aminolevulinic acid-based photodynamic therapy suppressed survival factors and activated proteases for apoptosis in human glioblastoma U87MG cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Death receptors: signaling and modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19777160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-009-9324-7

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

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