Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma. (Q43087591)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18073349%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma (English)

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29 December 2019

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29 December 2019

Beatrice Saposnik

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29 December 2019

Elodie Lesteven

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29 December 2019

Anna Lokajczyk

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29 December 2019

Charles T Esmon

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29 December 2019

Martine Aiach

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29 December 2019

language of work or name

English

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publication date

11 December 2007

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29 December 2019

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29 December 2019

volume

111

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29 December 2019

issue

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29 December 2019

page(s)

3442-3451

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Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3.

29 December 2019

cites work

1 reference

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Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17.

25 May 2018

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The endothelial protein C receptor

25 May 2018

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Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

25 May 2018

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The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype

25 May 2018

1 reference

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Mechanisms of soluble cytokine receptor generation

25 May 2018

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The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

25 May 2018

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Structure and functions of the endothelial cell protein C receptor

25 May 2018

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Coagulation and inflammation

25 May 2018

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Functional properties of the sex-hormone-binding globulin (SHBG)-like domain of the anticoagulant protein S.

25 May 2018

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Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.

25 May 2018

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

25 May 2018

1 reference

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Endothelial cell protein C receptor plays an important role in protein C activation in vivo

25 May 2018

1 reference

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The soluble interleukin 6 receptor: mechanisms of production and implications in disease

25 May 2018

1 reference

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Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor

25 May 2018

1 reference

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Expression and characterization of recombinant protein S with the Ser 460 Pro mutation.

25 May 2018

1 reference

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The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18

25 May 2018

1 reference

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Metalloproteolytic release of endothelial cell protein C receptor

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275013

Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275013

Organization and chromosomal localization of the human endothelial protein C receptor gene

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275013

Structural prediction and analysis of endothelial cell protein C/activated protein C receptor

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275013

Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275013

Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway

25 May 2018

1 reference

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Identification of functional endothelial protein C receptor in human plasma

25 May 2018

1 reference

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Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

25 May 2018

1 reference

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A new technique for the assay of infectivity of human adenovirus 5 DNA

25 May 2018

1 reference

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Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin

25 May 2018

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Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation

25 May 2018

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PAR1 cleavage and signaling in response to activated protein C and thrombin.

15 August 2018

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Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor and circulating activated protein C levels, and thrombotic risk

15 August 2018

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Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2.

15 August 2018

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An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN.

15 August 2018

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Inhibition of activated protein C anticoagulant activity by prothrombin

15 August 2018

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12 December 2020

Bimodal distribution of soluble endothelial protein C receptor levels in healthy populations

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12 December 2020

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis

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12 December 2020

Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis

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12 December 2020

The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor

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12 December 2020

The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors

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12 December 2020

Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes

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12 December 2020

Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1

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12 December 2020

10.1182/BLOOD-2007-08-104968

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18073349%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

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29 December 2019

PubMed publication ID

18073349

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18073349%20AND%20SRC:MED&resulttype=core&format=json