The pleiotropic protein kinase CK2 phosphorylates HTLV-1 Tax protein in vitro, targeting its PDZ-binding motif (Q43043529)

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scientific article published on 5 June 2010

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English	The pleiotropic protein kinase CK2 phosphorylates HTLV-1 Tax protein in vitro, targeting its PDZ-binding motif	scientific article published on 5 June 2010

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instance of

scholarly article

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Europe PubMed Central

PubMed publication ID

20526659

retrieved

12 November 2017

title

The pleiotropic protein kinase CK2 phosphorylates HTLV-1 Tax protein in vitro, targeting its PDZ-binding motif (English)

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

main subject

Human T-lymphotropic virus 1

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phosphorylation

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pleiotropy

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author

Mario A Pagano

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3

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

Lorenzo A Pinna

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6

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

Marco Mazzorana

object named as

Marco Mazzorana

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2

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Giorgio Arrigoni

object named as

Giorgio Arrigoni

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4

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author name string

Carlo Bidoia

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1

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

Flavio Meggio

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5

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

Umberto Bertazzoni

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7

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

publication date

5 June 2010

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

published in

Virus Genes

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

volume

41

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

issue

2

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

page(s)

149-157

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Europe PubMed Central

PubMed publication ID

20526659

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12 November 2017

cites work

Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Phosphorylated serine residues and an arginine-rich domain of the moloney murine leukemia virus p12 protein are required for early events of viral infection

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Protein kinase CK2: a challenge to canons

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Casein kinase 2 down-regulation and activation by polybasic peptides are mediated by acidic residues in the 55-64 region of the beta-subunit. A study with calmodulin as phosphorylatable substrate

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Development and exploitation of CK2 inhibitors

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Cell polarity proteins: common targets for tumorigenic human viruses

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Protein kinase CK2 as a druggable target

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Molecular mechanisms of cellular transformation by HTLV-1 Tax.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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PDZ domains: structural modules for protein complex assembly

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Presence of a functional but dispensable nuclear export signal in the HTLV-2 Tax protein

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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Protein kinase CK2 in health and disease: CK2: a key player in cancer biology

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The consensus sequences for cdc2 kinase and for casein kinase-2 are mutually incompatible. A study with peptides derived from the beta-subunit of casein kinase-2

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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The PDZ domain binding motif (PBM) of human T-cell leukemia virus type 1 Tax can be substituted by heterologous PBMs from viral oncoproteins during T-cell transformation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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Abundant synthesis of functional human T-cell leukemia virus type I p40x protein in eucaryotic cells by using a baculovirus expression vector

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for phosphorylation of trans-activator p40x of human T-cell leukemia virus type I produced in insect cells with a baculovirus expression vector

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One-thousand-and-one substrates of protein kinase CK2?

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioactive peptides from libraries.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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Central Role of a Serine Phosphorylation Site within Duck Hepatitis B Virus Core Protein for Capsid Trafficking and Genome Release

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

based on heuristic

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Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Clustal W and Clustal X version 2.0

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20526659

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12 December 2020

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Identifiers

DOI

10.1007/S11262-010-0494-3

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Europe PubMed Central

PubMed publication ID

20526659

retrieved

12 November 2017

Dimensions Publication ID

1040574898

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PubMed publication ID

20526659

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Europe PubMed Central

PubMed publication ID

20526659

retrieved

12 November 2017

ResearchGate publication ID

44652546

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