Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation (Q42872080)

9 November 2017

Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation (English)

1 reference

9 November 2017

1 reference

C. A. Spek

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

27 November 2024

G. L. van Sluis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

27 November 2024

L. W. Brüggemann

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

27 November 2024

C. T. Esmon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

27 November 2024

P. W. Kamphuisen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

27 November 2024

D. J. Richel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

27 November 2024

H. R. Büller

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

27 November 2024

C. J F. van Noorden

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

27 November 2024

language of work or name

English

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publication date

21 March 2011

1 reference

PMC publication ID

3159049

full work available at URL

9 November 2017

https://europepmc.org/articles/pmc3159049?pdf=render

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

https://europepmc.org/articles/PMC3159049

27 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

https://europepmc.org/articles/PMC3159049?pdf=render

27 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

https://doi.org/10.1016/j.canlet.2011.02.038

27 November 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21420234

https://api.elsevier.com/content/article/PII:S0304383511001339?httpAccept=text/xml

27 November 2024

1 reference

10.1016/J.CANLET.2011.02.038

Crossref

DOI

https://api.crossref.org/works/10.1016/J.CANLET.2011.02.038

https://api.elsevier.com/content/article/PII:S0304383511001339?httpAccept=text/plain

27 November 2024

1 reference

10.1016/J.CANLET.2011.02.038

Crossref

DOI

https://api.crossref.org/works/10.1016/J.CANLET.2011.02.038

27 November 2024

1 reference

9 November 2017

306

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9 November 2017

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9 November 2017

106-110

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Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement

9 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Mechanisms linking tumor cell-associated procoagulant function to tumor dissemination

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Twist is required for thrombin-induced tumor angiogenesis and growth

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Thrombin-induced cell proliferation and platelet-derived growth factor-AB release from A172 human glioblastoma cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Cancer and thrombosis: from molecular mechanisms to clinical presentations

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

The effect of low-molecular-weight heparin on cancer survival. A systematic review and meta-analysis of randomized trials

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Activated protein C signals through the thrombin receptor PAR1 in endothelial cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Coagulation proteases and human cancer

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Effect of different types of thrombin inhibitors on thrombin/thrombomodulin modulated activation of protein C in vitro

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

In vivo natural killer cell activities revealed by natural killer cell-deficient mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Arrest and extravasation of B16 amelanotic melanoma in murine lungs. A light and electron microscopic study

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Pharmacology and toxicology of a defibrinating substance from Malayan pit viper venom.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Role of activated protein C and its receptor in inhibition of tumor metastasis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Protein kinase C modifications of VE-cadherin, p120, and β-catenin contribute to endothelial barrier dysregulation induced by thrombin

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Inhibition of endothelial cell-mediated generation of activated protein C by direct and antithrombin-dependent thrombin inhibitors

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159049

Pretreatment of rabbits with either hirudin, ancrod, or warfarin significantly reduces the immediate uptake of fibrinogen and platelets by the deendothelialized aorta wall after balloon-catheter injury in vivo

16 August 2018

1 reference

12 December 2020

Lysis of tumor cells by natural killer cells in mice is impeded by platelets

1 reference

12 December 2020

Thrombin inhibitors suppress the thrombin-thrombomodulin-mediated generation of activated protein C

1 reference

12 December 2020

Lymphocyte phenotyping and NK cell activity analysis in pregnant NOD/SCID mice

1 reference

12 December 2020

A coagulation factor VII deficiency protects against acute inflammatory responses in mice

1 reference

12 December 2020

Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway

1 reference

12 December 2020

Redundant signaling of tissue factor and thrombin in cancer progression?

1 reference

12 December 2020

High factor VIIa levels do not promote tumor metastasis

1 reference

12 December 2020

Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function

1 reference

12 December 2020

10.1016/J.CANLET.2011.02.038

Identifiers

DOI

1 reference

9 November 2017

1 reference

PMC publication ID

3159049

9 November 2017

1 reference

PMC publication ID

3159049