Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice (Q42840235)

8 November 2017

Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice (English)

1 reference

8 November 2017

Ramón A Espinoza-Lewis

object named as

Ramón A. Espinoza-Lewis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21640717

3 December 2024

Kai Jiao

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21640717

3 December 2024

Hongbing Liu

1 reference

8 November 2017

Cheng Sun

1 reference

8 November 2017

Chaohui Chen

1 reference

8 November 2017

YiPing Chen

1 reference

8 November 2017

language of work or name

English

0 references

publication date

26 May 2011

1 reference

full work available at URL

8 November 2017

https://doi.org/10.1016/j.ydbio.2011.05.663

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21640717

https://europepmc.org/articles/PMC3143305

3 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21640717

https://europepmc.org/articles/PMC3143305?pdf=render

3 December 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21640717

https://api.elsevier.com/content/article/PII:S001216061100978X?httpAccept=text/xml

3 December 2024

1 reference

10.1016/J.YDBIO.2011.05.663

DOI

https://api.crossref.org/works/10.1016/J.YDBIO.2011.05.663

https://api.elsevier.com/content/article/PII:S001216061100978X?httpAccept=text/plain

3 December 2024

1 reference

10.1016/J.YDBIO.2011.05.663

DOI

https://api.crossref.org/works/10.1016/J.YDBIO.2011.05.663

3 December 2024

published in

Developmental Biology

1 reference

8 November 2017

356

1 reference

8 November 2017

1 reference

8 November 2017

359-369

1 reference

Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart

8 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Molecular pathway for the localized formation of the sinoatrial node

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Mode and determination of the initial contraction stage in the mouse embryo heart

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

T-box transcription factors and their roles in regulatory hierarchies in the developing heart

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Cell cycle control by homeobox genes in development and disease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

An essential role of Bmp4 in the atrioventricular septation of the mouse heart

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Two novel frameshift mutations in NKX2.5 result in novel features including visceral inversus and sinus venosus type ASD

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Congenital heart disease caused by mutations in the transcription factor NKX2-5

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

A new human homeobox gene OGI2X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Cloning and characterization of four murine homeobox genes

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Csx: a murine homeobox-containing gene specifically expressed in the developing heart

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Reconstruction of the patterns of gene expression in the developing mouse heart reveals an architectural arrangement that facilitates the understanding of atrial malformations and arrhythmias

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Comparative studies on the expression patterns of three troponin T genes during mouse development.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

The morphologic development of the sinoatrial node in the mouse

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143305

The architectural development of the early mammalian heart

16 August 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.05.663

Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.05.663

Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.05.663

Location of pacemaker in chick embryo heart at the time of initiation of heartbeat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.05.663

Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.05.663

Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.05.663

Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21640717

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.YDBIO.2011.05.663

1 reference

8 November 2017

1 reference

8 November 2017

1 reference