Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease (Q42818202)

7 November 2017

title

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease (English)

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7 November 2017

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7 November 2017

Ullrich Wüllner

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7 November 2017

Thomas Klockgether

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7 November 2017

Daniel Poppe

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Philipp Koch

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Jaideep Kesavan

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Jerome Mertens

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Oliver Brüstle

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7 November 2017

Julia Ladewig

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7 November 2017

Jonas Doerr

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7 November 2017

Michael Peitz

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7 November 2017

Peter Breuer

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7 November 2017

Johannes Jungverdorben

series ordinal

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7 November 2017

Thomas Tüting

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7 November 2017

Bernd O Evert

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7 November 2017

language of work or name

English

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publication date

23 November 2011

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7 November 2017

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7 November 2017

volume

480

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7 November 2017

issue

7378

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7 November 2017

page(s)

543-546

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describes a project that uses

7 November 2017

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Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.

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https://api.crossref.org/works/10.1038%2FNATURE10671

Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10671

Role of proteolysis in polyglutamine disorders

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10671

Diseases of unstable repeat expansion: mechanisms and common principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10671

Polyglutamine neurodegeneration: protein misfolding revisited.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10671

Neuronal calcium signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Mutational analysis of the structural organization of polyglutamine aggregates

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10671

Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Molecular chaperones in protein folding and proteostasis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10671

A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10671

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE10671

Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10671

Non-expanded polyglutamine proteins in intranuclear inclusions of hereditary ataxias--triple-labeling immunofluorescence study

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22113611

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intracellular inclusions, pathological markers in diseases caused by expanded polyglutamine tracts?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22113611

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE10671

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Dimensions Publication ID

7 November 2017

1025759625

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Fatcat ID

release_2gwqquradzhzjdzpxmlraoauaa

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Fatcat

https://api.fatcat.wiki/v0/release/2gwqquradzhzjdzpxmlraoauaa

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference