Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway (Q42801438)

7 November 2017

title

Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway (English)

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7 November 2017

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Lassus P

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7 November 2017

Roux P

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7 November 2017

Zugasti O

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7 November 2017

Philips A

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7 November 2017

Fort P

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7 November 2017

Hibner U

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7 November 2017

language of work or name

English

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publication date

1 May 2000

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7 November 2017

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7 November 2017

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7 November 2017

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7 November 2017

page(s)

2377-2385

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Death receptors: signaling and modulation

7 November 2017

cites work

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

21 January 2018

Phosphoinositide kinases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Ras signalling and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

A synthetic inhibitor of the mitogen-activated protein kinase cascade

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

PI3K: downstream AKTion blocks apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Rho GTPases and the Actin Cytoskeleton

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Suppression of Ras-induced apoptosis by the Rac GTPase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Oncogenic forms of p53 inhibit p53-regulated gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

21 January 2018

p53: puzzle and paradigm

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Detection and quantification of apoptosis in transiently transfected adherent cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

p53, the cellular gatekeeper for growth and division

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Social controls on cell survival and cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Apoptosis signaling by death receptors.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Apoptosis in the pathogenesis and treatment of disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

21 January 2018

A Bad kinase makes good

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

7 January 2021

A matter of life and cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

7 January 2021

p53; from inductive signal to cellular effect

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

7 January 2021

Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

7 January 2021

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203553

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203553

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Dimensions Publication ID

7 November 2017

1028966093

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