Pyroglutamate and O-linked glycan determine functional production of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions (Q42678311)

4 November 2017

Pyroglutamate and O-linked glycan determine functional production of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions (English)

1 reference

4 November 2017

Xiaotian Zhong

1 reference

4 November 2017

Elizabeth Kieras

1 reference

4 November 2017

Eric Sousa

1 reference

4 November 2017

Aaron D'Antona

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4 November 2017

J Christian Baber

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4 November 2017

Tao He

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4 November 2017

Joel Desharnais

1 reference

4 November 2017

Lauren Wood

1 reference

4 November 2017

Deborah Luxenberg

1 reference

4 November 2017

Mark Stahl

1 reference

4 November 2017

Ronald Kriz

1 reference

4 November 2017

Laura Lin

1 reference

4 November 2017

Will Somers

1 reference

4 November 2017

Lori J Fitz

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4 November 2017

Jill F Wright

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4 November 2017

language of work or name

English

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publication date

26 November 2012

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Journal of Biological Chemistry

4 November 2017

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inferred from page(s)

published in

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4 November 2017

288

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4 November 2017

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4 November 2017

1409-1419

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N-terminal Glutamate to Pyroglutamate Conversion in Vivo for Human IgG2 Antibodies

4 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Chemical generation of bispecific antibodies

27 May 2018

1 reference

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Functional biology of the IL-22-IL-22R pathway in regulating immunity and inflammation at barrier surfaces

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Cell engineering and cultivation of chinese hamster ovary (CHO) cells.

27 May 2018

1 reference

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A peptide-based erythropoietin-receptor agonist for pure red-cell aplasia

27 May 2018

1 reference

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Receptor-Fc fusion therapeutics, traps, and MIMETIBODY technology

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Structure of IL-17A in complex with a potent, fully human neutralizing antibody

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Interleukin-17 and type 17 helper T cells

27 May 2018

1 reference

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Romiplostim: a second-generation thrombopoietin agonist

27 May 2018

1 reference

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Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

27 May 2018

1 reference

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Th17 cytokines and their emerging roles in inflammation and autoimmunity

27 May 2018

1 reference

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27 May 2018

1 reference

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Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study

27 May 2018

1 reference

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Discovering and improving novel peptide therapeutics

27 May 2018

1 reference

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IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation

27 May 2018

1 reference

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The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics

27 May 2018

1 reference

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Protein therapeutics: a summary and pharmacological classification

27 May 2018

1 reference

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An extended dynamical hydration shell around proteins

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Albinterferon alpha-2b: a genetic fusion protein for the treatment of chronic hepatitis C.

27 May 2018

1 reference

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Comparison of mRNA-display-based selections using synthetic peptide and natural protein libraries

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target

27 May 2018

1 reference

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Bivalirudin for patients with acute coronary syndromes

27 May 2018

1 reference

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Post-translational modifications in the context of therapeutic proteins

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Potent antibody therapeutics by design

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Production of recombinant protein therapeutics in cultivated mammalian cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Fusion proteins comprising a Fusarium-specific antibody linked to antifungal peptides protect plants against a fungal pathogen

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

DNA display of biologically active proteins for in vitro protein selection

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

CIS display: In vitro selection of peptides from libraries of protein-DNA complexes

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Large-scale manufacture of peptide therapeutics by chemical synthesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Glycoprotein identification and localization of O-glycosylation sites by mass spectrometric analysis of deglycosylated/alkylaminylated peptide fragments

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

High avidity scFv multimers; diabodies and triabodies

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Concepts and principles of O-linked glycosylation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

RNA-peptide fusions for the in vitro selection of peptides and proteins

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Small peptides as potent mimetics of the protein hormone erythropoietin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

An in vitro polysome display system for identifying ligands from very large peptide libraries

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Therapeutic antibodies: past, present and future.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

To protect peptide pharmaceuticals against peptidases

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Repeated injections of PEG-PE liposomes generate anti-PEG antibodies.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543023

Generation of bispecific and tandem diabodies

16 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.417717

Short communication: renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated proteins

21 January 2018

1 reference

12 December 2020

Therapeutic peptides: the devil is in the details

1 reference

12 December 2020

IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration

1 reference

12 December 2020

Determination of the origin of the N-terminal pyro-glutamate variation in monoclonal antibodies using model peptides

1 reference

12 December 2020

An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment

1 reference

12 December 2020

Single-chain antibodies as diagnostic tools and therapeutic agents

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12 December 2020

IL-22 Induces an Acute-Phase Response

1 reference

12 December 2020

Improving biosensor analysis

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12 December 2020

Identifiers

DOI

10.1074/JBC.M112.417717

1 reference

4 November 2017

1 reference

4 November 2017

PubMed publication ID

23184956

1 reference