Lipopolysaccharide binding protein (Q4262879)

Bactericidal permeability-increasing protein, alpha/beta domain superfamily

1 reference

Lipid binding protein BPI/LBP

1 reference

Transporter Classification Database ID

1.C.40.1.2

2 October 2019

hierarchical database ID heuristic

Lipid-binding serum glycoprotein, C-terminal domain, protein family

1 reference

inferred from protein domain or family

Lipid-binding serum glycoprotein, N-terminal domain, protein family

1 reference

inferred from protein domain or family

Lipid-binding serum glycoprotein, conserved site, protein family

1 reference

inferred from protein domain or family

image

LBP protein.png
1,920 × 975; 585 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

lipoteichoic acid binding

1 reference

8 April 2019

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

lipid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

1 reference

8 April 2019

lipopolysaccharide binding

Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

lipopeptide binding

1 reference

8 April 2019

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

1 reference

8 April 2019

extracellular exosome

3 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18428&geneProductId=UniProtKB:P18428

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18428&geneProductId=UniProtKB:P18428

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18428&geneProductId=UniProtKB:P18428

extracellular space

Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

Structure and function of lipopolysaccharide binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

Lipopolysaccharide-binding protein increases toll-like receptor 4-dependent activation by nontypeable Haemophilus influenzae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

detection of molecule of bacterial origin

biological process

1 reference

8 April 2019

Lipopolysaccharide-binding protein increases toll-like receptor 4-dependent activation by nontypeable Haemophilus influenzae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

lipid transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

1 reference

8 April 2019

toll-like receptor 4 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

1 reference

8 April 2019

TAS

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

1 reference

8 April 2019

leukocyte chemotaxis involved in inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

cellular defense response

1 reference

8 April 2019

Structure and function of lipopolysaccharide binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

cellular response to lipoteichoic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

defense response to bacterium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

1 reference

8 April 2019

lipopolysaccharide transport

1 reference

8 April 2019

Lipopolysaccharide-binding protein mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

positive regulation of interleukin-8 production

1 reference

8 April 2019

Antagonistic effects of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein on lipopolysaccharide-induced cytokine release by mononuclear phagocytes. Competition for binding to lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

positive regulation of interleukin-6 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

positive regulation of neutrophil chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

positive regulation of toll-like receptor 4 signaling pathway

1 reference

8 April 2019

Lipopolysaccharide-binding protein increases toll-like receptor 4-dependent activation by nontypeable Haemophilus influenzae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

positive regulation of chemokine production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

negative regulation of tumor necrosis factor production

1 reference

8 April 2019

High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

lipopolysaccharide-mediated signaling pathway

2 references

8 April 2019

High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

opsonization

defense response to Gram-negative bacterium

Structure and function of lipopolysaccharide binding protein

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

Lipopolysaccharide-binding protein increases toll-like receptor 4-dependent activation by nontypeable Haemophilus influenzae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

positive regulation of tumor necrosis factor production

Structure and function of lipopolysaccharide binding protein

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

response to lipopolysaccharide

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

macrophage activation involved in immune response

Structure and function of lipopolysaccharide binding protein

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

acute-phase response

Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

innate immune response

Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

cellular response to lipopolysaccharide

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

positive regulation of macrophage activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

1 reference

8 April 2019

macromolecule localization

TAS

1 reference

8 April 2019

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

positive regulation of cytolysis

1 reference

8 April 2019

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18428&geneProductId=UniProtKB:P18428

1 reference

26 September 2017

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18428

1 reference

8 April 2019

Lipid-binding serum glycoprotein, conserved site

TAS

Gene Atlas image

PBB GE LBP 214461 at fs.png
732 × 530; 8 KB

0 references

has part(s)

1 reference

Lipid-binding serum glycoprotein, N-terminal

1 reference

Lipid-binding serum glycoprotein, C-terminal

1 reference

http://www.uniprot.org/uniprot/Q61805.txt?version=120

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

28 October 2013

1 reference

10 November 2015

Transporter Classification Database ID

1.C.40.1.2

2 references

Transporter Classification database

13 March 2020

Transporter Classification database