The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin (Q42619428)

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scientific article published on June 1997

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English	The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin	scientific article published on June 1997

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scholarly article

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4 November 2019

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin (English)

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4 November 2019

Bernard Le Bonniec

4

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4 November 2019

Milton T Stubbs

7

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4 November 2019

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van de Locht A

1

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4 November 2019

Bode W

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4 November 2019

Huber R

3

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4 November 2019

Stone SR

5

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4 November 2019

Esmon CT

6

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4 November 2019

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1 June 1997

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4 November 2019

The EMBO Journal

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4 November 2019

16

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4 November 2019

11

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4 November 2019

2977-2984

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4 November 2019

Kinetics of the reaction between trypsin and the pancreatic trypsin inhibitor

1 reference

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27 May 2018

The ornithodorin-thrombin crystal structure, a key to the TAP enigma?

1 reference

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27 May 2018

Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design

1 reference

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27 May 2018

Tryptophan 60-D in the B-insertion loop of thrombin modulates the thrombin-antithrombin reaction

1 reference

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Divining the serpin inhibition mechanism: a suicide substrate 'springe'?

1 reference

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27 May 2018

A player of many parts: the spotlight falls on thrombin's structure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

Evidence for common structural changes in thrombin induced by active-site or exosite binding

1 reference

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27 May 2018

The clot thickens: clues provided by thrombin structure.

1 reference

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27 May 2018

Disulfide bond isomerization in BPTI and BPTI(G36S): an NMR study of correlated mobility in proteins.

1 reference

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27 May 2018

Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin

1 reference

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27 May 2018

Thermodynamic investigation of hirudin binding to the slow and fast forms of thrombin: evidence for folding transitions in the inhibitor and protease coupled to binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder

1 reference

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27 May 2018

Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

The roles of protein C and thrombomodulin in the regulation of blood coagulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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27 May 2018

The coagulation cascade: initiation, maintenance, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

Refined structure of the hirudin-thrombin complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

The interaction of thrombin with fibrinogen. A structural basis for its specificity

1 reference

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27 May 2018

Natural protein proteinase inhibitors and their interaction with proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

Thrombin is a Na(+)-activated enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

27 May 2018

Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1169916

16 August 2018

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution.

1 reference

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16 August 2018

Use of fragments of hirudin to investigate thrombin-hirudin interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/9214615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of the inhibition of alpha-thrombin by hirudin-derived fragments hirudin(1-47) and hirudin(45-65)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9214615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin Glu-39 restricts the P'3 specificity to nonacidic residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/9214615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9214615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9214615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Occupancy of anion binding exosite 2 on thrombin determines Ca2+ dependence of protein C activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9214615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational transitions linked to active site ligation in human thrombin: effect on the interaction with fibrinogen and the cleavable platelet receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9214615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/EMBOJ/16.11.2977

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Europe PubMed Central

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4 November 2019

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Europe PubMed Central

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4 November 2019

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4 November 2019

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