Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons (Q42602928)

3 November 2017

title

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons (English)

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3 November 2017

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3 November 2017

Sina Bavari

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3 November 2017

Peter Wipf

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3 November 2017

James C Burnett

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3 November 2017

Gordon Ruthel

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3 November 2017

Christian M Stegmann

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3 November 2017

Rekha G Panchal

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3 November 2017

Tam L Nguyen

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3 November 2017

Ann R Hermone

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3 November 2017

Robert G Stafford

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3 November 2017

Douglas J Lane

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3 November 2017

Tara A Kenny

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3 November 2017

Connor F McGrath

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3 November 2017

Andrea M Stahl

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3 November 2017

James J Schmidt

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3 November 2017

Rick Gussio

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3 November 2017

language of work or name

English

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publication date

8 November 2006

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Journal of Biological Chemistry

3 November 2017

published in

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3 November 2017

volume

282

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3 November 2017

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3 November 2017

page(s)

5004-5014

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Therapy and prophylaxis of inhaled biological toxins

3 November 2017

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Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity

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Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

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Substrate recognition strategy for botulinum neurotoxin serotype A.

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Fluorigenic substrates for the protease activities of botulinum neurotoxins, serotypes A, B, and F.

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Synthesis of substrates and inhibitors of botulinum neurotoxin type A metalloprotease

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Biologically active novel conformational state of botulinum, the most poisonous poison

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Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A.

21 January 2018

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Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry

21 January 2018

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Partial protection against Botulinum B neurotoxin-induced blocking of exocytosis by a potent inhibitor of its metallopeptidase activity

21 January 2018

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Dynamics of motor nerve terminal remodeling unveiled using SNARE-cleaving botulinum toxins: the extent and duration are dictated by the sites of SNAP-25 truncation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M608166200

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3 November 2017

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