Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays (Q42505249)

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English	Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays	scientific article

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scholarly article

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1 November 2017

Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays (English)

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1 November 2017

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Alexandra Burkard

1

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Caroline Dähn

2

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Stefan Heinz

3

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Anne Zutavern

4

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1 November 2017

Vera Sonntag-Buck

5

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1 November 2017

Daniel Maltman

6

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1 November 2017

Stefan Przyborski

7

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1 November 2017

Nicola J Hewitt

8

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1 November 2017

Joris Braspenning

9

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1 November 2017

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publication date

24 April 2012

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1 November 2017

42

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10

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1 November 2017

939-956

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1 November 2017

Novel cell culture device enabling three-dimensional cell growth and improved cell function.

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Hepatotoxicity associated with antiepileptic drugs

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Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells.

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Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-Antigen gene transfer.

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Isolation, characterization, and differentiation to hepatocyte-like cells of nonparenchymal epithelial cells from adult human liver.

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Implication of CYP 3A in the toxicity of cyclosporin G (CsG), cyclosporin A (CsA) and FK506 on rat hepatocytes in primary culture

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Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes

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Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells

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Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo

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In vitro differentiation of human cord blood-derived unrestricted somatic stem cells into hepatocyte-like cells on poly(epsilon-caprolactone) nanofiber scaffolds.

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Isolation and characterization of a stem cell population from adult human liver

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Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes

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Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

1 reference

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Drug metabolism in hepatocyte sandwich cultures of rats and humans

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Epithelial cells with hepatobiliary phenotype: is it another stem cell candidate for healthy adult human liver?

1 reference

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Molecular characterization and inhibition of amanitin uptake into human hepatocytes

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Human hepatocytes: isolation, cryopreservation and applications in drug development

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Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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A prospective study of antituberculous drug-induced hepatotoxicity in an area endemic for liver diseases

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Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes

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Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction

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Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition

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Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use.

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Hepatotoxicity of psychotropic drugs

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Emergency department visits for antibiotic-associated adverse events

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Investigation of rifampicin-induced hepatotoxicity in rat hepatocytes maintained in gel entrapment culture

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A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines

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Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines

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Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver

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Characterisation of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. I. Glucose metabolism and enzyme release as cytotoxic markers.

1 reference

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7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes

1 reference

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Liposomes modulate docetaxel-induced lipid oxidization and membrane damage in human hepatoma cells

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Differential methotrexate hepatotoxicity on rat hepatocytes in 2-D monolayer culture and 3-D gel entrapment culture.

1 reference

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In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney

1 reference

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Anticonvulsant drugs and liver damage (Author's transl)

1 reference

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Presence of markers for liver progenitor cells in human-derived intrahepatic biliary epithelial cells

1 reference

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21 January 2018

Identifiers

10.3109/00498254.2012.675093

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

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