Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing (Q42496595)

1 November 2017

title

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing (English)

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1 November 2017

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Margarida Serra

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Catarina Brito

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Rui M Tostões

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1 November 2017

Sofia B Leite

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Janne Jensen

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Petter Björquist

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1 November 2017

language of work or name

English

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publication date

1 April 2012

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1 November 2017

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1 November 2017

page(s)

1227-1236

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Human hepatocytes as a tool for studying toxicity and drug metabolism.

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cites work

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Towards an extended functional hepatocyte in vitro culture

21 January 2018

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Structural polarity and functional bile canaliculi in rat hepatocyte spheroids

21 January 2018

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Ultrastructural and functional investigations of adult hepatocyte spheroids during in vitro cultivation

21 January 2018

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Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants

21 January 2018

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Secretion of albumin and induction of CYP1A2 and CYP3A4 in novel three-dimensional culture system for human hepatocytes using micro-space plate

21 January 2018

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Perfused multiwell plate for 3D liver tissue engineering

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Microscale culture of human liver cells for drug development

21 January 2018

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Artificial and bioartificial liver devices: present and future

21 January 2018

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Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies.

21 January 2018

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Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

21 January 2018

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Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system.

21 January 2018

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Modeling mass transfer in hepatocyte spheroids via cell viability, spheroid size, and hepatocellular functions

21 January 2018

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Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: Improved in vitro models for toxicological applications.

21 January 2018

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Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.

21 January 2018

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Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

21 January 2018

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Induction of three-dimensional assembly of human liver cells by simulated microgravity

21 January 2018

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Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor

21 January 2018

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Effect of human patient plasma ex vivo treatment on gene expression and progenitor cell activation of primary human liver cells in multi-compartment 3D perfusion bioreactors for extra-corporeal liver support

21 January 2018

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Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors

21 January 2018

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Enhanced cytochrome P450 IA1 activity of self-assembled rat hepatocyte spheroids

21 January 2018

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7 January 2021

Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration

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7 January 2021

Efficient assembly of rat hepatocyte spheroids for tissue engineering applications

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7 January 2021

A device to measure the oxygen uptake rate of attached cells: importance in bioartificial organ design.

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7 January 2021

Role of oxygen in the zonation of carbohydrate metabolism and gene expression in liver

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7 January 2021

Metabolic heterogeneity of hepatocytes across the liver acinus

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7 January 2021

Identifiers

DOI

10.1002/HEP.24760

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1 November 2017

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