Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter (Q42496506)

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English	Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter	scientific article

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PubMed publication ID

16757812

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1 November 2017

title

Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter (English)

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PubMed publication ID

16757812

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1 November 2017

author

Bryan Maloney

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1

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PubMed publication ID

16757812

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1 November 2017

author name string

Yuan-Wen Ge

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2

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Europe PubMed Central

PubMed publication ID

16757812

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1 November 2017

Nigel H Greig

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3

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Europe PubMed Central

PubMed publication ID

16757812

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1 November 2017

Debomoy K Lahiri

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4

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Europe PubMed Central

PubMed publication ID

16757812

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1 November 2017

publication date

1 January 2006

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Europe PubMed Central

PubMed publication ID

16757812

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1 November 2017

published in

Journal of Molecular Neuroscience

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stated in

Europe PubMed Central

PubMed publication ID

16757812

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1 November 2017

volume

29

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Europe PubMed Central

PubMed publication ID

16757812

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1 November 2017

issue

1

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Europe PubMed Central

PubMed publication ID

16757812

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1 November 2017

page(s)

81-99

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Europe PubMed Central

PubMed publication ID

16757812

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1 November 2017

cites work

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

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inferred from PubMed ID database lookup

Efficient DNA transfection in neuronal and astrocytic cell lines

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CENSOR--a program for identification and elimination of repetitive elements from DNA sequences

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA sequence and comparative analysis of chimpanzee chromosome 22.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE-2 is overexpressed in Down's syndrome.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased vulnerability of neuronal cell lines to sodium nitroprusside-mediated toxicity is caused by the decreased level of nitric oxide metabolites

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An improved sequence assembly program.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of beta-secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association studies using novel polymorphisms in BACE1 and BACE2.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 and BACE2 in pathologic and normal human muscle

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 gene promoter is differentially regulated: detection of a novel promoter region for its cell type-specific regulation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the 5'-flanking region of the beta-amyloid precursor protein gene that contributes to increased promoter activity in differentiated neuronal cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EMBOSS: the European Molecular Biology Open Software Suite

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression analysis of BACE2 in brain and peripheral tissues

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of BACE1 and BACE2 in muscle fibres of patients with sporadic inclusion-body myositis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three organizations of human DNA.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple sequence alignment with Clustal X

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of beta-amyloid deposition in the medial temporal lobe in sporadic Alzheimer's disease, Down's syndrome and normal elderly brains

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene structure and organization of the human beta-secretase (BACE) promoter.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16757812

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1385/JMN:29:1:81

1 reference

stated in

Europe PubMed Central

PubMed publication ID

16757812

retrieved

1 November 2017

Dimensions Publication ID

1027768760

0 references

PubMed publication ID

16757812

1 reference

stated in

Europe PubMed Central

PubMed publication ID

16757812

retrieved

1 November 2017

 

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