Sodium ion binding pocket mutations and adenosine A2A receptor function. (Q42469733)

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scientific article published on 3 December 2014

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English	Sodium ion binding pocket mutations and adenosine A2A receptor function.	scientific article published on 3 December 2014

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instance of

scholarly article

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stated in

Europe PubMed Central

PubMed publication ID

25473121

retrieved

1 November 2017

title

Sodium ion binding pocket mutations and adenosine A2A receptor function (English)

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stated in

Europe PubMed Central

PMC publication ID

6067640

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

retrieved

12 May 2020

main subject

binding pocket

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inferred from title

author

Hugo Gutiérrez de Terán

series ordinal

2

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Europe PubMed Central

PMC publication ID

6067640

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

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12 May 2020

Vsevolod Katritch

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7

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PMC publication ID

6067640

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

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12 May 2020

Raymond C. Stevens

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8

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PMC publication ID

6067640

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12 May 2020

Adriaan P IJzerman

series ordinal

9

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Europe PubMed Central

PMC publication ID

6067640

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

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12 May 2020

Laura H Heitman

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6

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Laura H Heitman

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PMC publication ID

6067640

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

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12 May 2020

Arnault Massink

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1

object named as

Arnault Massink

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Europe PubMed Central

PMC publication ID

6067640

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

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12 May 2020

Lizi Xia

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5

object named as

Lizi Xia

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6067640

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12 May 2020

author name string

Eelke B Lenselink

series ordinal

3

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Europe PubMed Central

PMC publication ID

6067640

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

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12 May 2020

Natalia V Ortiz Zacarías

series ordinal

4

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Europe PubMed Central

PMC publication ID

6067640

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

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12 May 2020

publication date

3 December 2014

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Europe PubMed Central

PubMed publication ID

25473121

retrieved

1 November 2017

published in

Molecular Pharmacology

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stated in

Europe PubMed Central

PMC publication ID

6067640

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

retrieved

12 May 2020

volume

87

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Europe PubMed Central

PMC publication ID

6067640

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

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12 May 2020

issue

2

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Europe PubMed Central

PMC publication ID

6067640

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

retrieved

12 May 2020

page(s)

305-313

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Europe PubMed Central

PMC publication ID

6067640

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

retrieved

12 May 2020

cites work

Site-directed mutagenesis studies of human A(2A) adenosine receptors: involvement of glu(13) and his(278) in ligand binding and sodium modulation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

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The binding-site crevice of the D4 dopamine receptor is coupled to three distinct sites of allosteric modulation

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PubMed

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12 December 2020

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Determination of amino acid residues that are accessible from the ligand binding crevice in the seventh transmembrane-spanning region of the human A(1) adenosine receptor

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

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Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

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Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

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An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

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Small revisions to predicted distances around metal sites in proteins

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

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Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors

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12 December 2020

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An ion-responsive motif in the second transmembrane segment of rhodopsin-like receptors

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

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Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

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Ligand binding and micro-switches in 7TM receptor structures

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

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The structure and function of G-protein-coupled receptors

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An iris-like mechanism of pore dilation in the CorA magnesium transport system

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

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Induced effects of sodium ions on dopaminergic G-protein coupled receptors

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of an agonist-bound human A2A adenosine receptor

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Dynamics Simulations Reveal Insights into Key Structural Elements of Adenosine Receptors

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

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Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

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An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

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Trends in the exploitation of novel drug targets

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

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A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A(2a) receptor.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function of the G protein-coupled receptor superfamily

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

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High-resolution crystal structure of human protease-activated receptor 1

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the dynamic events of GPCRs by automated computational simulations

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biophysical Fragment Screening of the β 1 -Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine receptors as drug targets--what are the challenges?

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GPCRDB: an information system for G protein-coupled receptors

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular control of δ-opioid receptor signalling

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric sodium in class A GPCR signaling

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of protein using bicinchoninic acid

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VMD: visual molecular dynamics

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognition

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis of the human A1 adenosine receptor: influences of acidic and hydroxy residues in the first four transmembrane domains on ligand binding

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25473121

retrieved

12 December 2020

based on heuristic

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Identifiers

DOI

10.1124/MOL.114.095737

1 reference

stated in

Europe PubMed Central

PMC publication ID

6067640

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

retrieved

12 May 2020

PMC publication ID

6067640

1 reference

stated in

Europe PubMed Central

PMC publication ID

6067640

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

retrieved

12 May 2020

PubMed publication ID

25473121

1 reference

stated in

Europe PubMed Central

PMC publication ID

6067640

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6067640&resulttype=core&format=json

retrieved

12 May 2020

 

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