Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells. (Q42271523)

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7 January 2020

title

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells (English)

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7 January 2020

author

Qiang Pan-Hammarström

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7 January 2020

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7 January 2020

Lennart Hammarström

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7 January 2020

Andrew R Gennery

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7 January 2020

Aleksi Lähdesmäki

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7 January 2020

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Anne-Marie Jones

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7 January 2020

Wei Zhou

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7 January 2020

Richard A Gatti

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7 January 2020

language of work or name

English

0 references

publication date

1 January 2005

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Journal of Experimental Medicine

7 January 2020

published in

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7 January 2020

volume

201

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7 January 2020

issue

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7 January 2020

page(s)

189-194

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Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

7 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

26 October 2017

1 reference

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Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.

26 October 2017

1 reference

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Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

Mechanism and regulation of human non-homologous DNA end-joining

26 October 2017

1 reference

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Impact of DNA ligase IV on the fidelity of end joining in human cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

26 October 2017

1 reference

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Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

26 October 2017

1 reference

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DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

26 October 2017

1 reference

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

26 October 2017

1 reference

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Lucky breaks: analysis of recombination in Saccharomyces

26 October 2017

1 reference

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Targeting of human switch recombination breakpoints: implications for the mechanism of mu-gamma isotype switching

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

Delineation of the role of the Mre11 complex in class switch recombination

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4.

17 August 2018

1 reference

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Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212791

Characterization of human gamma 4 switch region polymorphisms suggests a meiotic recombinational hot spot within the Ig locus: influence of S region length on IgG4 production.

17 August 2018

1 reference

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V(D)J Recombination in Ku86-Deficient Mice: Distinct Effects on Coding, Signal, and Hybrid Joint Formation

17 August 2018

1 reference

12 December 2020

Regulation of switching and production of IgA in human B cells in donors with duplicated alpha1 genes

1 reference

12 December 2020

Alternative end joining during switch recombination in patients with ataxia-telangiectasia

1 reference

12 December 2020

Allotype-associated variation in the human gamma3 switch region as a basis for differences in IgG3 production

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20040772

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15657289%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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7 January 2020

PubMed publication ID

15657289

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