Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch (Q42275889)

19 October 2017

title

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch (English)

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19 October 2017

Marco Fischer

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Bojana Durovic

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Sarah Dimeloe

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Patrick M Gubser

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19 October 2017

Glenn R Bantug

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19 October 2017

Leyla Razik

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19 October 2017

Gideon Hoenger

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19 October 2017

Annaïse Jauch

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19 October 2017

Christoph Hess

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19 October 2017

language of work or name

English

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publication date

18 August 2013

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19 October 2017

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19 October 2017

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19 October 2017

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19 October 2017

page(s)

1064-1072

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Inflaming the CD8+ T cell response.

19 October 2017

cites work

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Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection

21 January 2018

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Fuel feeds function: energy metabolism and the T-cell response

21 January 2018

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Homeostatic control of lymphocyte survival: potential origins and implications

21 January 2018

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Regulation of T lymphocyte metabolism

21 January 2018

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The CD28 signaling pathway regulates glucose metabolism

21 January 2018

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Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

21 January 2018

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Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

21 January 2018

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Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphate pathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells

21 January 2018

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

21 January 2018

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Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

21 January 2018

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Hidden memories: frontline memory T cells and early pathogen interception

21 January 2018

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Dynamics of blood-borne CD8 memory T cell migration in vivo.

21 January 2018

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Preferential localization of effector memory cells in nonlymphoid tissue

21 January 2018

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Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets

21 January 2018

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Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

21 January 2018

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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

21 January 2018

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Subcellular dynamics of multifunctional protein regulation: mechanisms of GAPDH intracellular translocation

21 January 2018

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Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function

21 January 2018

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Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes

21 January 2018

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PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

21 January 2018

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PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

21 January 2018

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

1 reference

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin

21 January 2018

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Diversity in T cell memory: an embarrassment of riches

21 January 2018

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Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

21 January 2018

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Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure

21 January 2018

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Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells

21 January 2018

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Posttranscriptional control of T cell effector function by aerobic glycolysis

21 January 2018

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Direct visualization of cytokine-producing recall antigen-specific CD4 memory T cells in healthy individuals and HIV patients.

21 January 2018

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Sirtuin 1 in immune regulation and autoimmunity

21 January 2018

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Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response

21 January 2018

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The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation

21 January 2018

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Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression

21 January 2018

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Cutting Edge: Persistently Open Chromatin at Effector Gene Loci in Resting Memory CD8+ T Cells Independent of Transcriptional Status

21 January 2018

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ATP-citrate lyase links cellular metabolism to histone acetylation

21 January 2018

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

21 January 2018

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Memory CD8+ T cells require CD28 costimulation.

21 January 2018

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The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus

21 January 2018

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Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c

21 January 2018

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Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

21 January 2018

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Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis.

21 January 2018

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Metabolic regulation of epigenetics

21 January 2018

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Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti- CD3 mAb T-cell expansion and "RecycleSpot"

21 January 2018

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Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

21 January 2018

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12 December 2020

Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines

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12 December 2020

Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production

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12 December 2020

Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase: a role in high glucose-induced apoptosis in retinal Müller cells

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12 December 2020

Identifiers

DOI

10.1038/NI.2687

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19 October 2017

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