Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction (Q42216959)

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scientific article published on July 2010

Language	Label	Description	Also known as
English	Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction	scientific article published on July 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction (English)

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

4

object named as

Yali Dou

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

author name string

Hacer Karatas

1

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Elizabeth C Townsend

2

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Denzil Bernard

3

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Shaomeng Wang

5

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

language of work or name

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publication date

1 July 2010

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Europe PubMed Central

PMC publication ID

18 October 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

53

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

14

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

5179-5185

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

HOXA9 is required for survival in human MLL-rearranged acute leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Downstream of homeotic genes: in the heart of Hox function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Hox genes in hematopoiesis and leukemogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Chromatin modifications and their function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Histone H3 Lys 4 methylation: caught in a bind?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Structural basis for molecular recognition and presentation of histone H3 by WDR5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Regulation of MLL1 H3K4 methyltransferase activity by its core components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Molecular recognition of histone H3 by the WD40 protein WDR5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Global and Hox-specific roles for the MLL1 methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

MLL: a histone methyltransferase disrupted in leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Beyond homeosis--HOX function in morphogenesis and organogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

Translating the Histone Code

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

The oncogenic potential of deregulated homeobox genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

26 October 2017

WDR5, a complexed protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

17 August 2018

Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

17 August 2018

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

17 August 2018

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289617

17 August 2018

Expression of homeobox-containing genes in primary and metastatic colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20575550

12 December 2020

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Identifiers

10.1021/JM100139B

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

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