Synergistic interaction between the two mechanisms of action of tapentadol in analgesia (Q42182000)

18 October 2017

Synergistic interaction between the two mechanisms of action of tapentadol in analgesia (English)

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18 October 2017

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18 October 2017

W Schröder

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T M Tzschentke

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18 October 2017

R Terlinden

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18 October 2017

J De Vry

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18 October 2017

U Jahnel

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18 October 2017

T Christoph

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18 October 2017

language of work or name

English

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publication date

24 January 2011

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Journal of Pharmacology and Experimental Therapeutics

18 October 2017

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18 October 2017

337

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18 October 2017

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18 October 2017

312-320

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The application of drug dose equivalence in the quantitative analysis of receptor occupation and drug combinations

18 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Tapentadol immediate release for the relief of moderate-to-severe acute pain

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: a 10-day, phase III, randomized, double-blind, active- and placebo-cont

26 October 2017

1 reference

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The use of occupation isoboles for analysis of a response mediated by two receptors: M2 and M3 muscarinic receptor subtype-induced mouse stomach contractions

26 October 2017

1 reference

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(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Interactions between drugs and occupied receptors

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

An overview of drug combination analysis with isobolograms

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids

26 October 2017

1 reference

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Opioids in chronic non-cancer pain: systematic review of efficacy and safety

26 October 2017

1 reference

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Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice

26 October 2017

1 reference

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Descending control of pain

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Drug synergism: its detection and applications

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Evidence-based data on pain relief with antidepressants

26 October 2017

1 reference

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Opioid therapy for chronic nonmalignant pain: a review of the critical issues

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Thoracic epidural clonidine and morphine for postoperative pain relief

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Ethical guidelines for investigations of experimental pain in conscious animals

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Addition of clonidine enhances postoperative analgesia from epidural morphine: a double-blind study.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Tapentadol, but not morphine, selectively inhibits disease-related thermal hyperalgesia in a mouse model of diabetic neuropathic pain

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Desipramine enhances opiate postoperative analgesia

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

An isobolographic analysis of the antinociceptive effect of systemically and intrathecally administered combinations of clonidine and opiates

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Central and systemic morphine-induced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Unbound brain concentration determines receptor occupancy: a correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Isobolographic analysis for combinations of a full and partial agonist: curved isoboles

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

The induction of pain: an integrative review

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Augmentation of central and peripheral morphine analgesia by desipramine

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364495

Analgesic properties of intrathecally administered heterocyclic antidepressants

17 August 2018

1 reference

12 December 2020

Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man

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12 December 2020

The antinociceptive effects of morphine, desipramine, and serotonin and their combinations after intrathecal injection in the rat

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12 December 2020

Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine

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12 December 2020

The problem of synergism and antagonism of combined drugs

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12 December 2020

Antagonisms and antagonists

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12 December 2020

Tolerability of tapentadol immediate release in patients with lower back pain or osteoarthritis of the hip or knee over 90 days: a randomized, double-blind study

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12 December 2020

Identifiers

DOI

10.1124/JPET.110.175042

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18 October 2017

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18 October 2017

PubMed publication ID

21262850

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