Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling (Q42174682)

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scientific article published on 20 August 2009

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English	Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling	scientific article published on 20 August 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling (English)

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Nico van Rooijen

3

object named as

Nico van Rooijen

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

author name string

Alicia H Clementi

1

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Allison M Gaudy

2

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Europe PubMed Central

PMC publication ID

18 October 2017

Robert H Pierce

4

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Robert A Mooney

5

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Europe PubMed Central

PMC publication ID

18 October 2017

publication date

20 August 2009

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Europe PubMed Central

PMC publication ID

18 October 2017

number of pages

11

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inferred from page(s)

Biochimica et Biophysica Acta

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Europe PubMed Central

PMC publication ID

18 October 2017

1792

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Europe PubMed Central

PMC publication ID

18 October 2017

11

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

1062-1072

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763970

26 October 2017

Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow

1 reference

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26 October 2017

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

1 reference

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26 October 2017

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

1 reference

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26 October 2017

Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance

1 reference

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26 October 2017

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

1 reference

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26 October 2017

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

1 reference

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Structure and function of Toll receptors and their ligands

1 reference

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26 October 2017

Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome

1 reference

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26 October 2017

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

1 reference

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26 October 2017

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26 October 2017

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

1 reference

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26 October 2017

Reactive oxygen species have a causal role in multiple forms of insulin resistance

1 reference

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26 October 2017

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

1 reference

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26 October 2017

A TNF-induced gene expression program under oscillatory NF-kappaB control

1 reference

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26 October 2017

Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease

1 reference

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26 October 2017

Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation?

1 reference

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26 October 2017

Interleukin-6 depletion selectively improves hepatic insulin action in obesity

1 reference

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26 October 2017

Liver immunobiology

1 reference

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26 October 2017

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

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26 October 2017

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

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26 October 2017

Adipokines: inflammation and the pleiotropic role of white adipose tissue

1 reference

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26 October 2017

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763970

26 October 2017

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763970

26 October 2017

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

1 reference

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26 October 2017

The many faces of macrophage activation

1 reference

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26 October 2017

Alternative activation of macrophages

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26 October 2017

Interleukin-6 induces cellular insulin resistance in hepatocytes

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26 October 2017

A central role for JNK in obesity and insulin resistance

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26 October 2017

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

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26 October 2017

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

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26 October 2017

Signal transduction by tumor necrosis factor and its relatives

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26 October 2017

The liver as an immune organ

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26 October 2017

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

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26 October 2017

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30 September 2018

Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes

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26 October 2017

Resolution of inflammation.

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26 October 2017

M-1/M-2 macrophages and the Th1/Th2 paradigm

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26 October 2017

Troglitazone action is independent of adipose tissue

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26 October 2017

Specific inhibition of Stat3 signal transduction by PIAS3

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26 October 2017

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses

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26 October 2017

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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26 October 2017

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

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26 October 2017

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

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26 October 2017

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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26 October 2017

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha

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26 October 2017

Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling

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29 May 2018

Inhibition of LPS-induced nitric oxide and TNF-alpha production by alpha-lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages

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Gadolinium Chloride Toxicity in the Rat

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Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins

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29 May 2018

Critical role of Kupffer cells in the management of diet-induced diabetes and obesity.

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17 August 2018

Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice.

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17 August 2018

Interleukin-10 is a protective factor against diet-induced insulin resistance in liver

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17 August 2018

Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice

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17 August 2018

Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver

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Circulating mononuclear cells in the obese are in a proinflammatory state

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Kupffer cell-derived prostaglandin E2 is involved in regulation of lipid synthesis in rat liver tissue

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Expression pattern and regulation of heme oxygenase-1/heat shock protein 32 in human liver cells

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Hepatic allograft-derived Kupffer cells regulate T cell response in rats

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Inhibition of IL-6 signaling by a p38-dependent pathway occurs in the absence of new protein synthesis

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Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro

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17 August 2018

Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study

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Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

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Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha

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12 December 2020

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https://pubmed.ncbi.nlm.nih.gov/19699298

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Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

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Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression

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Identifiers

10.1016/J.BBADIS.2009.08.007

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

ResearchGate publication ID

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