Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase (Q42156581)

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English	Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

17 October 2017

Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase (English)

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

author name string

Lionel Kuntz

1

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Europe PubMed Central

PMC publication ID

17 October 2017

Denis Tritsch

2

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Europe PubMed Central

PMC publication ID

17 October 2017

Catherine Grosdemange-Billiard

3

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Andréa Hemmerlin

4

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Audrey Willem

5

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Thomas J Bach

6

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Europe PubMed Central

PMC publication ID

17 October 2017

Michel Rohmer

7

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Europe PubMed Central

PMC publication ID

17 October 2017

language of work or name

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publication date

1 February 2005

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Europe PubMed Central

PMC publication ID

17 October 2017

Biochemical Journal

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Europe PubMed Central

PMC publication ID

17 October 2017

386

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Europe PubMed Central

PMC publication ID

17 October 2017

Pt 1

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Europe PubMed Central

PMC publication ID

17 October 2017

127-135

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Isoprenoid biosynthesis as a novel target for antibacterial and antiparasitic drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

Fosmidomycin for the treatment of malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.

1 reference

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29 May 2018

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

Fosmidomycin, a novel chemotherapeutic agent for malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin

1 reference

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29 May 2018

E. coli MEP synthase: steady-state kinetic analysis and substrate binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

Deoxyxylulose phosphate pathway to terpenoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants

1 reference

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29 May 2018

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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29 May 2018

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

1 reference

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29 May 2018

The crystal structure of plant acetohydroxy acid isomeroreductase complexed with NADPH, two magnesium ions and a herbicidal transition state analog determined at 1.65Aresolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

Slow-binding inhibition: the general case.

1 reference

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29 May 2018

Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification

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29 May 2018

Interactions of plant acetohydroxy acid isomeroreductase with reaction intermediate analogues: correlation of the slow, competitive, inhibition kinetics of enzyme activity and herbicidal effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

The mechanism of action of fosfomycin (phosphonomycin)

1 reference

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29 May 2018

Distribution of an Inducible Hexose-Phosphate Transport System Among Various Bacteria

1 reference

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29 May 2018

The behavior and significance of slow-binding enzyme inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

Transcription of glpT of Escherichia coli K12 is regulated by anaerobiosis and fnr.

1 reference

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29 May 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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29 May 2018

A new antifungal antibiotic, trichostatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

29 May 2018

Isoprenoid biosynthesis via the MEP pathway. Synthesis of (3,4)-3,4-dihydroxy-5-oxohexylphosphonic acid, an isosteric analogue of 1-deoxy-D-xylulose 5-phosphate, the substrate of the 1-deoxy-D-xylulose 5-phosphate reducto-isomerase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

17 August 2018

Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants ofEscherichia coli

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134774

17 August 2018

Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase

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17 August 2018

Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase

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17 August 2018

N-Aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: further probing of the S(1), S(1)', and S(2)' pockets

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17 August 2018

Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity

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17 August 2018

Isolation of the dxr gene of Zymomonas mobilis and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

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17 August 2018

[Mechanism of fosfomycin-resistance in clinical isolates].

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17 August 2018

Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues

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12 December 2020

based on heuristic

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Studies on new phosphonic acid antibiotics. III. Isolation and characterization of FR-31564, FR-32863 and FR-33289

1 reference

https://pubmed.ncbi.nlm.nih.gov/15473867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of bacterial isoprenoid synthesis by fosmidomycin, a phosphonic acid-containing antibiotic

1 reference

https://pubmed.ncbi.nlm.nih.gov/15473867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxalyl hydroxamates as reaction-intermediate analogues for ketol-acid reductoisomerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15473867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fosfomycin resistance in Escherichia coli in Japan

1 reference

https://pubmed.ncbi.nlm.nih.gov/15473867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20041378

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

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