A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin (Q42137647)

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scientific article published on December 2005

Language	Label	Description	Also known as
English	A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin	scientific article published on December 2005

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin (English)

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

0 references

author name string

Amanda L McClerren

1

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Stephanie Endsley

2

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Jason L Bowman

3

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Niels H Andersen

4

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Ziqiang Guan

5

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Johannes Rudolph

6

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Christian R H Raetz

7

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

language of work or name

0 references

publication date

1 December 2005

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

44

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

50

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

16574-16583

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Mechanistic basis of enzyme-targeted drugs

1 reference

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UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.

1 reference

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29 May 2018

Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.

1 reference

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29 May 2018

Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway

1 reference

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29 May 2018

Zinc hydrolases: the mechanisms of zinc-dependent deacetylases

1 reference

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Conditional lethal amber mutations in essential Escherichia coli genes

1 reference

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Targeting metalloenzymes: a strategy that works

1 reference

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Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis

1 reference

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The quinolones: decades of development and use

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High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties

1 reference

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New (and not so new) antibacterial targets - from where and when will the novel drugs come?

1 reference

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Hydroxamic acids as pharmacological agents

1 reference

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Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.

1 reference

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29 May 2018

Lipopolysaccharide endotoxins

1 reference

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29 May 2018

Antibacterial activities and characterization of novel inhibitors of LpxC.

1 reference

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29 May 2018

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

1 reference

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29 May 2018

Aminoglycosides: activity and resistance

1 reference

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29 May 2018

UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme

1 reference

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29 May 2018

Structure of peptide deformylase and identification of the substrate binding site

1 reference

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The complete genome of the hyperthermophilic bacterium Aquifex aeolicus

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The complete genome sequence of Escherichia coli K-12

1 reference

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29 May 2018

The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742919

29 May 2018

Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis

1 reference

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29 May 2018

Biosynthesis of lipid A in Escherichia coli: identification of UDP-3-O-[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine as a precursor of UDP-N2,O3-bis[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine

1 reference

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The behavior and significance of slow-binding enzyme inhibitors

1 reference

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The design and properties of N-carboxyalkyldipeptide inhibitors of angiotensin-converting enzyme

1 reference

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Sequence analysis, transcriptional organization, and insertional mutagenesis of the envA gene of Escherichia coli

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The crisis in antibiotic resistance

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29 May 2018

Antibacterial agents that inhibit lipid A biosynthesis.

1 reference

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29 May 2018

Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.

1 reference

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Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis.

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Antimicrobials: new solutions badly needed

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Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups

1 reference

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Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site

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UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable.

1 reference

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Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16342948

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Where will new antibiotics come from?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16342948

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI0518186

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

ResearchGate publication ID

0 references

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