Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure (Q42081779)

16 October 2017

Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure (English)

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16 October 2017

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1 June 2020

Ting Liu

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1 June 2020

Eiki Takimoto

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1 June 2020

Veronica L Dimaano

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1 June 2020

Deeptankar DeMazumder

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1 June 2020

Sarah Kettlewell

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1 June 2020

Godfrey Smith

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1 June 2020

Agnieszka Sidor

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1 June 2020

Theodore P Abraham

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1 June 2020

publication date

29 April 2014

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16 October 2017

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1 June 2020

volume

115

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1 June 2020

issue

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1 June 2020

page(s)

44-54

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Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.

1 June 2020

cites work

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Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress

30 May 2018

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Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress

30 May 2018

1 reference

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Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia

30 May 2018

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Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy

30 May 2018

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Bioenergetics of the failing heart

30 May 2018

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30 May 2018

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Mitochondria in heart failure

30 May 2018

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Experimental models of spontaneous ventricular arrhythmias and of sudden cardiac death.

30 May 2018

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Role of mitochondrial dysfunction in cardiac glycoside toxicity

30 May 2018

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Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes

30 May 2018

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Regulation of intracellular and mitochondrial sodium in health and disease

30 May 2018

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Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure.

30 May 2018

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The role of Na dysregulation in cardiac disease and how it impacts electrophysiology

30 May 2018

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Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching

30 May 2018

1 reference

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Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load.

30 May 2018

1 reference

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Mitochondrial centrality in heart failure

30 May 2018

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Excitation-contraction coupling and mitochondrial energetics

30 May 2018

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QRS and QTc interval prolongation in the prediction of long-term mortality of patients with acute destabilised heart failure

30 May 2018

1 reference

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Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects.

30 May 2018

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Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance

30 May 2018

1 reference

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Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes

30 May 2018

1 reference

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Oxidative stress and redox signalling in cardiac hypertrophy and heart failure.

30 May 2018

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Cardiac repolarization. The long and short of it.

30 May 2018

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Mechanisms and models in heart failure: the biomechanical model and beyond

30 May 2018

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Oxygen, oxidative stress, hypoxia, and heart failure

30 May 2018

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ATP flux through creatine kinase in the normal, stressed, and failing human heart

30 May 2018

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Is the failing heart energy starved? On using chemical energy to support cardiac function

30 May 2018

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Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis

30 May 2018

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Abnormal calcium signaling and sudden cardiac death associated with mutation of calsequestrin

30 May 2018

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Altered function and regulation of cardiac ryanodine receptors in cardiac disease

30 May 2018

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Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes

30 May 2018

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[Na+]i handling in the failing human heart

30 May 2018

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Role of oxidative stress in myocardial hypertrophy and failure

30 May 2018

1 reference

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30 May 2018

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30 May 2018

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30 May 2018

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Na+ effects on mitochondrial respiration and oxidative phosphorylation in diabetic hearts

30 May 2018

1 reference

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Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

30 May 2018

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Medical management of mild-to-moderate heart failure before the advent of beta blockers

30 May 2018

1 reference

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Measurement of the QT interval and the risk associated with QTc interval prolongation: a review

30 May 2018

1 reference

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Why patients with congestive heart failure die: arrhythmias and sudden cardiac death

30 May 2018

1 reference

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Contribution of the translocator of adenine nucleotides and the ATP synthase to the control of oxidative phosphorylation and arsenylation in liver mitochondria.

30 May 2018

1 reference

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Ca2+ as a second messenger within mitochondria of the heart and other tissues

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219273

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

30 May 2018

1 reference

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Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219273

Beta-adrenergic activation initiates chamber dilatation in concentric hypertrophy.

17 August 2018

1 reference

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Qtc interval as a guide to select those patients with congestive heart failure and reduced left ventricular systolic function who will benefit from antiarrhythmic treatment with dofetilide

17 August 2018

1 reference

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Mechanism of death in heart failure. The Vasodilator-Heart Failure Trials. The V-HeFT VA Cooperative Studies Group

17 August 2018

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12 December 2020

QT variability strongly predicts sudden cardiac death in asymptomatic subjects with mild or moderate left ventricular systolic dysfunction: a prospective study

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12 December 2020

beta(2)-adrenergic receptor overexpression exacerbates development of heart failure after aortic stenosis

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12 December 2020

Targeting mitochondrial oxidative stress in heart failure throttling the afterburner

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12 December 2020

Hypertension and sudden death. Increased ventricular ectopic activity in left ventricular hypertrophy

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12 December 2020

Role of mitochondrial calcium transport in the control of substrate oxidation

1 reference

12 December 2020

A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria

1 reference

12 December 2020

Is the failing heart an energy-starved organ?

1 reference

12 December 2020

Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase

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12 December 2020

Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity

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12 December 2020

10.1161/CIRCRESAHA.115.303062

Identifiers

DOI

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1 June 2020

1 reference

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1 June 2020

PubMed publication ID

24780171

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